P
Payam Fathi
Researcher at Johns Hopkins University
Publications - 17
Citations - 1578
Payam Fathi is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Bacteroides fragilis & Internal medicine. The author has an hindex of 9, co-authored 14 publications receiving 1008 citations. Previous affiliations of Payam Fathi include Johns Hopkins University School of Medicine & University of Maryland, College Park.
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Journal ArticleDOI
Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria
Christine M. Dejea,Payam Fathi,John M. Craig,Annemarie Boleij,Annemarie Boleij,Rahwa Taddese,Abby L. Geis,Xinqun Wu,Christina E. DeStefano Shields,Elizabeth M. Hechenbleikner,David L. Huso,Robert A. Anders,Francis M. Giardiello,Elizabeth C. Wick,Hao Wang,Shaoguang Wu,Drew M. Pardoll,Franck Housseau,Cynthia L. Sears +18 more
TL;DR: Genes for colibactin and Bacteroides fragilis toxin, encoding secreted oncotoxins, were highly enriched in FAP patients’ colonic mucosa compared to healthy individuals, suggesting an unexpected link between early neoplasia of the colon and tumorigenic bacteria.
Journal ArticleDOI
Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells.
Liam Chung,Erik Thiele Orberg,Abby L. Geis,June L. Chan,Kai Fu,Christina E. DeStefano Shields,Christine M. Dejea,Payam Fathi,Jie Chen,Benjamin B. Finard,Ada J. Tam,Florencia McAllister,Hongni Fan,Xinqun Wu,Sudipto Ganguly,Sudipto Ganguly,Andriana Lebid,Paul Metz,Sara W. Van Meerbeke,David L. Huso,Elizabeth C. Wick,Drew M. Pardoll,Drew M. Pardoll,Fengyi Wan,Shaoguang Wu,Cynthia L. Sears,Franck Housseau,Franck Housseau +27 more
TL;DR: It is shown that the Bacteroides fragilis toxin (BFT) triggers a pro-carcinogenic, multi-step inflammatory cascade requiring IL-17R, NF-κB, and Stat3 signaling in colonic epithelial cells (CECs), which collectively triggers myeloid-cell-dependent distal colon tumorigenesis.
Journal ArticleDOI
High-resolution bacterial 16S rRNA gene profile meta-analysis and biofilm status reveal common colorectal cancer consortia.
Julia L. Drewes,James R. White,Christine M. Dejea,Payam Fathi,Thevambiga Iyadorai,Jamuna Vadivelu,April Camilla Roslani,Elizabeth C. Wick,Emmanuel F. Mongodin,Mun Fai Loke,Kumar Thulasi,Han Ming Gan,Khean-Lee Goh,Hoong Yin Chong,Sandip Kumar,Jane W. Wanyiri,Cynthia L. Sears +16 more
TL;DR: Researchers in the USA and Malaysia found that bowel cancers were enriched in invasive bacterial biofilms as well as several specific gut and oral species, including one - Fusobacterium nucleatum - known to promote tumorigenesis in mouse models.
Journal ArticleDOI
Human colon mucosal biofilms from healthy or colon cancer hosts are carcinogenic
Sarah Tomkovich,Christine M. Dejea,Kathryn Winglee,Julia L. Drewes,Liam Chung,Franck Housseau,Jillian L. Pope,Josee Gauthier,Xiaolun Sun,Marcus Mühlbauer,Xiuli Liu,Payam Fathi,Robert A. Anders,Sepideh Besharati,Ernesto Perez-Chanona,Ye Yang,Hua Ding,Xinqun Wu,Shaoguang Wu,James R. White,Raad Z. Gharaibeh,Anthony A. Fodor,Hao Wang,Drew M. Pardoll,Christian Jobin,Cynthia L. Sears +25 more
TL;DR: The results suggest human colon mucosal biofilms, whether from tumor hosts or healthy individuals undergoing screening colonoscopy, are carcinogenic in murine models of CRC.
Journal ArticleDOI
The myeloid immune signature of enterotoxigenic Bacteroides fragilis-induced murine colon tumorigenesis.
E. Thiele Orberg,Hongni Fan,Ada Tam,Christine M. Dejea,C E Destefano Shields,Shaoguang Wu,Liam Chung,Benjamin B. Finard,Xinqun Wu,Payam Fathi,Sudipto Ganguly,Juan Fu,Drew M. Pardoll,Cynthia L. Sears,Franck Housseau +14 more
TL;DR: Enterotoxigenic Bacteroides fragilis (ETBF), a human commensal and candidate pathogen in colorectal cancer (CRC), is a potent initiator of interleukin-17 (IL-17)-dependent colon tumorigenesis in MinApc+/− mice, which is associated with an IL-17-driven myeloid signature characterized by subversion of steady-state myelopoiesis.