P
Payel Datta
Researcher at Rensselaer Polytechnic Institute
Publications - 20
Citations - 416
Payel Datta is an academic researcher from Rensselaer Polytechnic Institute. The author has contributed to research in topics: Heparin & Heparan sulfate. The author has an hindex of 8, co-authored 19 publications receiving 317 citations.
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Journal ArticleDOI
An 'omics approach towards CHO cell engineering
TL;DR: This review paper discusses the recent advances in bioengineering strategies in CHO cell lines and the impact of the knowledge gained by CHO cell genomics, transcriptomics, and glycomics on the future of CHO‐cell engineering.
Journal ArticleDOI
Metabolic engineering of Chinese hamster ovary cells: Towards a bioengineered heparin
Jong Youn Baik,Leyla Gasimli,Bo Yang,Payel Datta,Fuming Zhang,Charles A. Glass,Jeffrey D. Esko,Robert J. Linhardt,Susan T. Sharfstein +8 more
TL;DR: Disaccharide analysis of the engineered HS showed a substantial increase in N-sulfo groups, but did not show a pattern consistent with pharmacological heparin, suggesting that further balancing the expression of transgenes with the expression levels of endogenous enzymes involved in HS/heparin biosynthesis might be necessary.
Journal ArticleDOI
Bioengineered Chinese Hamster Ovary Cells with Golgi-targeted 3-O-Sulfotransferase-1 Biosynthesize Heparan Sulfate with an Antithrombin-binding Site
Payel Datta,Guoyun Li,Guoyun Li,Bo Yang,Xue Zhao,Jong Youn Baik,Trent R. Gemmill,Susan T. Sharfstein,Robert J. Linhardt +8 more
TL;DR: It is demonstrated that untargeted HS3st1 is broadly distributed throughout CHO cells and forms no detectable AT-binding sites, whereas Golgi-targeted HS 3st1 localizes in the Golgi and results in the formation of a single type of AT- binding site and high anti-factor Xa activity.
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Optimization of bioprocess conditions improves production of a CHO cell-derived, bioengineered heparin
Jong Youn Baik,Hussain Dahodwala,Eziafa I. Oduah,Lee Talman,Trent R. Gemmill,Trent R. Gemmill,Leyla Gasimli,Payel Datta,Bo Yang,Guoyun Li,Fuming Zhang,Lingyun Li,Robert J. Linhardt,Andrew M. Campbell,Stephen F. Gorfien,Susan T. Sharfstein +15 more
TL;DR: Bioprocess optimization, in parallel with metabolic engineering refinements, will play a substantial role in developing a bioengineered heparin to replace the current animal-derived drug.
Journal ArticleDOI
Complete biosynthesis of a sulfated chondroitin in Escherichia coli.
Abinaya Badri,Asher Williams,Adeola Awofiranye,Payel Datta,Ke Xia,Wenqin He,Keith Fraser,Jonathan S. Dordick,Robert J. Linhardt,Mattheos A. G. Koffas +9 more
TL;DR: In this paper, the authors demonstrate the development of single microbial cell factories capable of complete, one-step biosynthesis of chondroitin sulfate (CS), a type of GAG.