P
Pedro J. Gonzalez-Cabrera
Researcher at Scripps Research Institute
Publications - 18
Citations - 1985
Pedro J. Gonzalez-Cabrera is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Receptor & Sphingosine-1-phosphate receptor. The author has an hindex of 15, co-authored 18 publications receiving 1870 citations. Previous affiliations of Pedro J. Gonzalez-Cabrera include University of California, San Diego & Novartis Foundation.
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Journal ArticleDOI
Sphingosine 1-Phosphate Receptor Signaling
TL;DR: The sphingosine 1-phosphate (S1P) receptor signaling system, based in part on receptor subtype-selectivity and on differential attenuation of deleterious signals, now appears to be on the cusp of meaningful therapy for multiple sclerosis.
Journal ArticleDOI
Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P 1 antagonist in vivo
M. Germana Sanna,Sheng-Kai Wang,Pedro J. Gonzalez-Cabrera,Pedro J. Gonzalez-Cabrera,Anthony S. Don,David Marsolais,Melanie P. Matheu,Sindy H. Wei,Ian Parker,Euijung Jo,Wei-Chieh Cheng,Michael D. Cahalan,Chi-Huey Wong,Hugh Rosen +13 more
TL;DR: Chemical modulation reveals differences in S1P-S1P1 'set points' among tissues and highlights both mechanistic advantages (lymphocyte sequestration) and risks (pulmonary edema) of therapeutic intervention.
Journal ArticleDOI
S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate.
Euijung Jo,M. Germana Sanna,Pedro J. Gonzalez-Cabrera,Shobha Thangada,Gabor Tigyi,Daniel A. Osborne,Timothy Hla,Abby L. Parrill,Hugh Rosen +8 more
TL;DR: SEW2871 recapitulates the action of S1P in all the signaling pathways examined and overlaps in interactions with key headgroup binding receptor residues, presumably replacing salt-bridge interactions with ion-dipole interactions.
Journal ArticleDOI
Tipping the gatekeeper: S1P regulation of endothelial barrier function.
TL;DR: This personal perspective highlights the pivotal control points regulated by constitutive and induced S1P receptor tone at vascular endothelial and lymphatic endothelial barriers, through which S 1P agonism impacts on both innate and adaptive immunity.
Journal ArticleDOI
Full Pharmacological Efficacy of a Novel S1P1 Agonist That Does Not Require S1P-Like Headgroup Interactions
Pedro J. Gonzalez-Cabrera,Euijung Jo,M. Germana Sanna,Steven D. Brown,Nora B. Leaf,David Marsolais,Marie-Therese Schaeffer,Jacqueline Chapman,Michael D. Cameron,Miguel Guerrero,Edward Roberts,Hugh Rosen +11 more
TL;DR: Data show that CYM-5442 activates S1P1-dependent pathways in vitro and to levels of full efficacy in vivo through a hydrophobic pocket separate from the orthosteric site of S 1P binding that is headgroup-dependent.