P
Peilin Li
Researcher at University of California, San Francisco
Publications - 13
Citations - 1106
Peilin Li is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Viral load & T cell. The author has an hindex of 11, co-authored 13 publications receiving 998 citations. Previous affiliations of Peilin Li include Veterans Health Administration & San Francisco VA Medical Center.
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Journal ArticleDOI
Differences in HIV Burden and Immune Activation within the Gut of HIV-Positive Patients Receiving Suppressive Antiretroviral Therapy
Steven A. Yukl,Steven A. Yukl,Sara Gianella,Sara Gianella,Elizabeth Sinclair,Lorrie Epling,Qingsheng Li,Lijie Duan,Alex Choi,Alex Choi,Valerie Girling,Terence Ho,Peilin Li,Peilin Li,Katsuya Fujimoto,Katsuya Fujimoto,Harry Lampiris,Harry Lampiris,C. Bradley Hare,Mark Pandori,Ashley T. Haase,Huldrych F. Günthard,Marek Fischer,Amandeep K. Shergill,Amandeep K. Shergill,Kenneth R. McQuaid,Kenneth R. McQuaid,Diane V. Havlir,Joseph K. Wong,Joseph K. Wong +29 more
TL;DR: The inverse relationship between HIV DNA levels and T cell activation in the gut and the paradoxically low levels of HIV expression in the large bowel suggest that different processes drive HIV persistence in the blood and gut.
Journal ArticleDOI
Challenges in Detecting HIV Persistence during Potentially Curative Interventions: A Study of the Berlin Patient
Steven A. Yukl,Eli Boritz,Michael P. Busch,Christopher Bentsen,Tae Wook Chun,Daniel C. Douek,Evelyn E. Eisele,Ashley T. Haase,Ya Chi Ho,Gero Hütter,J. Shawn Justement,Sheila M. Keating,Tzong-Hae Lee,Peilin Li,Danielle Murray,Sarah Palmer,Christopher D. Pilcher,Satish K. Pillai,Richard W. Price,Meghan K Rothenberger,Timothy W. Schacker,Janet M. Siliciano,Robert F. Siliciano,Robert F. Siliciano,Elizabeth Sinclair,Matthew C. Strain,Joseph K. Wong,Douglas D. Richman,Steven G. Deeks +28 more
TL;DR: The absence of recrudescent HIV replication and waning HIV-specific immune responses five years after withdrawal of treatment provide proof of a clinical cure.
Journal ArticleDOI
The Distribution of HIV DNA and RNA in Cell Subsets Differs in Gut and Blood of HIV-Positive Patients on ART: Implications for Viral Persistence
Steven A. Yukl,Amandeep K. Shergill,Terence Ho,Maudi Killian,Valerie Girling,Lorrie Epling,Peilin Li,Lisa K. Wong,Pierre Crouch,Steven G. Deeks,Diane V. Havlir,Kenneth R. McQuaid,Elizabeth Sinclair,Joseph K. Wong +13 more
TL;DR: Low levels of HIV DNA and RNA were observed in non-CD4+ T leukocytes at low levels, particularly in gut tissues, and future studies should determine whether different mechanisms allow HIV to persist in these distinct reservoirs, and the degree to which different therapies can affect each reservoir.
Journal ArticleDOI
Stimulating the RIG-I pathway to kill cells in the latent HIV reservoir following viral reactivation
Peilin Li,Philipp Kaiser,Harry Lampiris,Harry Lampiris,Peggy Kim,Steven A. Yukl,Steven A. Yukl,Diane V. Havlir,Warner C. Greene,Joseph K. Wong,Joseph K. Wong +10 more
TL;DR: It is shown that acitretin, an RA derivative approved by the US Food and Drug Administration, enhances RIG-I signaling ex vivo, increases HIV transcription, and induces preferential apoptosis of HIV-infected cells, which is abrogated by DDX58 knockdown.
Journal ArticleDOI
HIV-1 Drug Resistance in the iPrEx Preexposure Prophylaxis Trial
Teri Liegler,Mohamed Abdel-Mohsen,L. Gordon Bentley,Robert Atchison,Timothy T. Schmidt,Jacqueline Javier,Megha Mehrotra,Christopher Eden,David V. Glidden,Vanessa McMahan,Peter L. Anderson,Peilin Li,Joseph K. Wong,Susan Buchbinder,Juan V. Guanira,Robert M. Grant,Robert M. Grant +16 more
TL;DR: Drug resistance was rare in iPrEx on-study FTC/TDF-randomized seroconverters, and only as low-frequency minor variants, and among those initiating PrEP with acute infection waned rapidly after drug discontinuation.