P
Peter B. Noël
Researcher at University of Pennsylvania
Publications - 281
Citations - 5100
Peter B. Noël is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Iterative reconstruction & Imaging phantom. The author has an hindex of 31, co-authored 247 publications receiving 3731 citations. Previous affiliations of Peter B. Noël include Hospital of the University of Pennsylvania & University at Buffalo.
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Journal ArticleDOI
Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma
Pawel K. Mazur,Alexander Herner,Stephano S. Mello,Matthias Wirth,Simone Hausmann,Francisco J. Sánchez-Rivera,Shane Lofgren,Timo Kuschma,Stephan A. Hahn,Deepak Vangala,Marija Trajkovic-Arsic,Aayush Gupta,Irina Heid,Peter B. Noël,Rickmer Braren,Mert Erkan,Jörg Kleeff,Bence Sipos,Leanne C. Sayles,Mathias Heikenwalder,Mathias Heikenwalder,Elisabeth Heßmann,Volker Ellenrieder,Irene Esposito,Tyler Jacks,James E. Bradner,Purvesh Khatri,E. Alejandro Sweet-Cordero,Laura D. Attardi,Roland M Schmid,Roland M Schmid,Guenter Schneider,Julien Sage,Jens T. Siveke,Jens T. Siveke +34 more
TL;DR: The studies identify a promising epigenetic-based therapeutic strategy that may be rapidly implemented in fatal human tumors by using a CRISPR-Cas9–based method for gene editing directly in the mouse adult pancreas.
Journal ArticleDOI
The evolution of image reconstruction for CT—from filtered back projection to artificial intelligence
TL;DR: A concise look at the overall evolution of CT image reconstruction and its clinical implementations is taken, finding IR is essential for photon-counting CT, phase-contrast CT, and dark-field CT.
Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma
Pawel K. Mazur,Alexander Herner,Stephano S. Mello,Matthias Wirth,Simone Hausmann,Shane Lofgren,Timo Kuschma,Stephan A. Hahn,Deepak Vangala,Marija Trajkovic-Arsic,Aayush Gupta,Irina Heid,Peter B. Noël,Rickmer Braren,Mert Erkan,Jörg Kleeff,Bence Sipos,Leanne C. Sayles,Mathias Heikenwalder,Elizabeth Hessmann,Volker Ellenrieder,Irene Esposito,James E. Bradner,Purvesh Khatri,E. Alejandro Sweet-Cordero,Laura D. Attardi,Roland M Schmid,Guenter Schneider,Julien Sage,Jens T. Siveke,Francisco J. Sánchez-Rivera,Tyler Jacks +31 more
TL;DR: In this article, small-molecule inhibitors targeting chromatin regulators are tested as possible therapeutic agents in pancreatic ductal adenocarcinoma (PDAC) in mice.
Journal ArticleDOI
Initial Performance Characterization of a Clinical Noise–Suppressing Reconstruction Algorithm for MDCT
Peter B. Noël,Alexander A. Fingerle,Bernhard Renger,Daniela Münzel,Ernst J. Rummeny,Martin Dobritz +5 more
TL;DR: It is concluded that iDose is an important tool in the reduction of radiation dose in CT, however, continuous efforts to reduce radiation dose should be pursued.
Journal ArticleDOI
Spectral Photon-counting CT: Initial Experience with Dual–Contrast Agent K-Edge Colonography
Daniela Muenzel,Daniel Bar-Ness,Ewald Roessl,Ira Blevis,Matthias Bartels,Alexander A. Fingerle,Stefan Ruschke,Philippe Coulon,Heiner Daerr,Felix K. Kopp,Bernhard Brendel,Axel Thran,Michal Rokni,Julia Herzen,Loic Boussel,Franz Pfeiffer,Roland Proksa,Ernst J. Rummeny,Philippe Douek,Peter B. Noël +19 more
TL;DR: Dual-contrast spectral photon-counting CT colonography with iodine-filled lumen and gadolinium-tagged polyps may enable ready differentiation between polyps and tagged fecal material.