D
Deepak Vangala
Researcher at Ruhr University Bochum
Publications - 50
Citations - 1442
Deepak Vangala is an academic researcher from Ruhr University Bochum. The author has contributed to research in topics: Lynch syndrome & Medicine. The author has an hindex of 10, co-authored 35 publications receiving 913 citations.
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Journal ArticleDOI
Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database
Mev Dominguez-Valentin,Julian R. Sampson,Toni T. Seppälä,Sanne W. ten Broeke,John-Paul Plazzer,Sigve Nakken,Christoph Engel,Stefan Aretz,Mark A. Jenkins,Lone Sunde,Lone Sunde,Inge Bernstein,Gabriel Capellá,Francesc Balaguer,Huw D. Thomas,D. Gareth Evans,D. Gareth Evans,John Burn,Marc S. Greenblatt,Eivind Hovig,Wouter H. de Vos tot Nederveen Cappel,Rolf H. Sijmons,Lucio Bertario,Maria Grazia Tibiletti,Giulia Martina Cavestro,Annika Lindblom,Adriana Della Valle,Francisco López-Köstner,Nathan Gluck,Lior H. Katz,Karl Heinimann,Carlos A. Vaccaro,Reinhard Büttner,Heike Görgens,Elke Holinski-Feder,Monika Morak,Stefanie Holzapfel,Robert Hüneburg,Magnus von Knebel Doeberitz,Magnus von Knebel Doeberitz,Markus Loeffler,Nils Rahner,Hans K. Schackert,Verena Steinke-Lange,Wolff Schmiegel,Deepak Vangala,Kirsi Pylvänäinen,Laura Renkonen-Sinisalo,Laura Renkonen-Sinisalo,John L. Hopper,Aung Ko Win,Robert W. Haile,Noralane M. Lindor,Steven Gallinger,Loic Le Marchand,Polly A. Newcomb,Jane C. Figueiredo,Stephen N. Thibodeau,Karin Wadt,Christina Therkildsen,Henrik Okkels,Zohreh Ketabi,Leticia Moreira,Ariadna Sánchez,Miquel Serra-Burriel,Marta Pineda,Matilde Navarro,Ignacio Blanco,Kate Green,Fiona Lalloo,Emma J Crosbie,James Hill,Oliver G. Denton,Ian M. Frayling,Einar Andreas Rødland,Hans F. A. Vasen,Miriam Mints,Florencia Neffa,Patricia Esperon,Karin Alvarez,Revital Kariv,Guy Rosner,Tamara Alejandra Piñero,María Laura Gonzalez,Pablo Kalfayan,Douglas Tjandra,Ingrid Winship,Ingrid Winship,Finlay A. Macrae,Finlay A. Macrae,Gabriela Möslein,Jukka-Pekka Mecklin,Maartje Nielsen,Pål Møller,Pål Møller +94 more
TL;DR: Management guidelines for Lynch syndrome may require revision in light of these different gene and gender-specific risks and the good prognosis for the most commonly associated cancers.
Journal ArticleDOI
Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma
Pawel K. Mazur,Alexander Herner,Stephano S. Mello,Matthias Wirth,Simone Hausmann,Francisco J. Sánchez-Rivera,Shane Lofgren,Timo Kuschma,Stephan A. Hahn,Deepak Vangala,Marija Trajkovic-Arsic,Aayush Gupta,Irina Heid,Peter B. Noël,Rickmer Braren,Mert Erkan,Jörg Kleeff,Bence Sipos,Leanne C. Sayles,Mathias Heikenwalder,Mathias Heikenwalder,Elisabeth Heßmann,Volker Ellenrieder,Irene Esposito,Tyler Jacks,James E. Bradner,Purvesh Khatri,E. Alejandro Sweet-Cordero,Laura D. Attardi,Roland M Schmid,Roland M Schmid,Guenter Schneider,Julien Sage,Jens T. Siveke,Jens T. Siveke +34 more
TL;DR: The studies identify a promising epigenetic-based therapeutic strategy that may be rapidly implemented in fatal human tumors by using a CRISPR-Cas9–based method for gene editing directly in the mouse adult pancreas.
Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma
Pawel K. Mazur,Alexander Herner,Stephano S. Mello,Matthias Wirth,Simone Hausmann,Shane Lofgren,Timo Kuschma,Stephan A. Hahn,Deepak Vangala,Marija Trajkovic-Arsic,Aayush Gupta,Irina Heid,Peter B. Noël,Rickmer Braren,Mert Erkan,Jörg Kleeff,Bence Sipos,Leanne C. Sayles,Mathias Heikenwalder,Elizabeth Hessmann,Volker Ellenrieder,Irene Esposito,James E. Bradner,Purvesh Khatri,E. Alejandro Sweet-Cordero,Laura D. Attardi,Roland M Schmid,Guenter Schneider,Julien Sage,Jens T. Siveke,Francisco J. Sánchez-Rivera,Tyler Jacks +31 more
TL;DR: In this article, small-molecule inhibitors targeting chromatin regulators are tested as possible therapeutic agents in pancreatic ductal adenocarcinoma (PDAC) in mice.
Journal ArticleDOI
Blood-based detection of RAS mutations to guide anti-EGFR therapy in colorectal cancer patients: concordance of results from circulating tumor DNA and tissue-based RAS testing
Wolff Schmiegel,Rodney J. Scott,Rodney J. Scott,Susan Dooley,Wendy Lewis,Cliff Meldrum,Peter Pockney,Peter Pockney,Brian Draganic,Brian Draganic,Steve Smith,Steve Smith,Chelsee A. Hewitt,Hazel Philimore,Amanda Lucas,Elva Shi,Kateh Namdarian,Timmy Chan,Danilo Acosta,Su Ping-Chang,Andrea Tannapfel,Anke Reinacher-Schick,Waldemar Uhl,Christian Teschendorf,Heiner Wolters,Josef Stern,Richard Viebahn,Helmut Friess,Klaus-Peter Janssen,Ulrich Nitsche,Julia Slotta-Huspenina,Michael Pohl,Deepak Vangala,Alexander Baraniskin,Barbara Dockhorn-Dworniczak,S. Hegewisch-Becker,Philippe Ronga,Daniel L. Edelstein,Frederick S. Jones,Stephan A. Hahn,Stephen B. Fox +40 more
TL;DR: An accurate blood‐based RAS mutation assay to determine eligibility of metastatic colorectal cancer patients for anti‐EGFR therapy would benefit clinical practice by better informing decisions to administer treatment independent of tissue availability.
Journal ArticleDOI
Screening and surveillance in hereditary gastrointestinal cancers: Recommendations from the European Society of Digestive Oncology (ESDO) expert discussion at the 20th European Society for Medical Oncology (ESMO)/World Congress on Gastrointestinal Cancer, Barcelona, June 2018.
Deepak Vangala,Estelle Cauchin,Judith Balmaña,Lucian Wyrwicz,Eric Van Cutsem,Ulrich Güller,Antoni Castells,Fátima Carneiro,Pascal Hammel,Michel Ducreux,Jean-Luc Van Laethem,Tamara Matysiak-Budnik,Wolff Schmiegel +12 more
TL;DR: An international panel of experts and opinion leaders developed recommendations based on published evidence and on profound clinical expertise to facilitate clinical routine in identification and caretaking of patients with familial GI cancers.