S
Shane Lofgren
Researcher at Stanford University
Publications - 22
Citations - 1862
Shane Lofgren is an academic researcher from Stanford University. The author has contributed to research in topics: Deconvolution & Disease. The author has an hindex of 14, co-authored 21 publications receiving 1371 citations. Previous affiliations of Shane Lofgren include Bayer HealthCare Pharmaceuticals & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma
Pawel K. Mazur,Alexander Herner,Stephano S. Mello,Matthias Wirth,Simone Hausmann,Francisco J. Sánchez-Rivera,Shane Lofgren,Timo Kuschma,Stephan A. Hahn,Deepak Vangala,Marija Trajkovic-Arsic,Aayush Gupta,Irina Heid,Peter B. Noël,Rickmer Braren,Mert Erkan,Jörg Kleeff,Bence Sipos,Leanne C. Sayles,Mathias Heikenwalder,Mathias Heikenwalder,Elisabeth Heßmann,Volker Ellenrieder,Irene Esposito,Tyler Jacks,James E. Bradner,Purvesh Khatri,E. Alejandro Sweet-Cordero,Laura D. Attardi,Roland M Schmid,Roland M Schmid,Guenter Schneider,Julien Sage,Jens T. Siveke,Jens T. Siveke +34 more
TL;DR: The studies identify a promising epigenetic-based therapeutic strategy that may be rapidly implemented in fatal human tumors by using a CRISPR-Cas9–based method for gene editing directly in the mouse adult pancreas.
Journal ArticleDOI
CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer
Kipp Weiskopf,Nadine Jahchan,Peter J. Schnorr,Sandra Cristea,Aaron M. Ring,Roy Louis Maute,Anne Kathrin Volkmer,Jens Peter Volkmer,Jie Liu,Jing Shan Lim,Dian Yang,Garrett Seitz,Thuyen Nguyen,Di Wu,Kevin Jude,Heather Guerston,Amira A. Barkal,Francesca Trapani,Julie George,John T. Poirier,Eric E. Gardner,Linde A. Miles,Elisa de Stanchina,Shane Lofgren,Hannes Vogel,Monte M. Winslow,Caroline Dive,Roman K. Thomas,Charles M. Rudin,Matt van de Rijn,Ravindra Majeti,K. Christopher Garcia,Irving L. Weissman,Julien Sage +33 more
TL;DR: Disruption of the interaction of CD47 with SIRPα using anti-CD47 antibodies induced macrophage-mediated phagocytosis of human SCLC patient cells in culture, and this approach could enable personalized immunotherapeutic regimens in patients with S CLC and other cancers.
Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma
Pawel K. Mazur,Alexander Herner,Stephano S. Mello,Matthias Wirth,Simone Hausmann,Shane Lofgren,Timo Kuschma,Stephan A. Hahn,Deepak Vangala,Marija Trajkovic-Arsic,Aayush Gupta,Irina Heid,Peter B. Noël,Rickmer Braren,Mert Erkan,Jörg Kleeff,Bence Sipos,Leanne C. Sayles,Mathias Heikenwalder,Elizabeth Hessmann,Volker Ellenrieder,Irene Esposito,James E. Bradner,Purvesh Khatri,E. Alejandro Sweet-Cordero,Laura D. Attardi,Roland M Schmid,Guenter Schneider,Julien Sage,Jens T. Siveke,Francisco J. Sánchez-Rivera,Tyler Jacks +31 more
TL;DR: In this article, small-molecule inhibitors targeting chromatin regulators are tested as possible therapeutic agents in pancreatic ductal adenocarcinoma (PDAC) in mice.
Journal ArticleDOI
Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes.
Marvin H. Gee,Arnold Han,Shane Lofgren,John F. Beausang,Juan L. Mendoza,Michael E. Birnbaum,Michael T. Bethune,Suzanne Fischer,Xinbo Yang,Raquel Gomez-Eerland,David B. Bingham,Leah V. Sibener,Ricardo A. Fernandes,Andrew Velasco,David Baltimore,Ton N. Schumacher,Purvesh Khatri,Stephen R. Quake,Mark M. Davis,K. Christopher Garcia +19 more
TL;DR: It is shown that the exposed recognition surface of MHC-bound peptides accessible to the TCR contains sufficient structural information to enable the reconstruction of sequences of peptide targets for pathogenic TCRs of unknown specificity.
Journal ArticleDOI
Leveraging heterogeneity across multiple datasets increases cell-mixture deconvolution accuracy and reduces biological and technical biases.
Francesco Vallania,Andrew Tam,Shane Lofgren,Steven Schaffert,Tej D. Azad,Erika Bongen,Winston A. Haynes,Meia Alsup,Michael N. Alonso,Mark M. Davis,Edgar G. Engleman,Purvesh Khatri +11 more
TL;DR: In silico quantification of cell proportions from mixed-cell transcriptomics data (deconvolution) requires a reference expression matrix, called basis matrix, and introduces immunoStates, a basis matrix built using 6160 samples with different disease states across 42 microarray platforms that significantly reduces biological and technical biases.