P
Peter D. Adams
Researcher at University of Glasgow
Publications - 128
Citations - 20807
Peter D. Adams is an academic researcher from University of Glasgow. The author has contributed to research in topics: Senescence & Chromatin. The author has an hindex of 54, co-authored 115 publications receiving 17101 citations. Previous affiliations of Peter D. Adams include Discovery Institute & Fox Chase Cancer Center.
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Journal ArticleDOI
Retinoblastoma protein contains a C-terminal motif that targets it for phosphorylation by cyclin-cdk complexes.
Peter D. Adams,Xiaotong Li,William R. Sellers,Kayla B. Baker,Xiaohong Leng,J. Wade Harper,Yoichi Taya,William G. Kaelin +7 more
TL;DR: The C terminus of pRB contains a cyclin-cdk interaction motif of the type found in E2F1 and p21 that enables it to be recognized and phosphorylated by cyclin -cdk complexes.
Journal ArticleDOI
Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging.
TL;DR: The current understanding of the structure, assembly and function of these Senescence-Associated Heterochromatin Foci at a cellular level is reviewed.
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Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly.
Yong Tang,Maxim Poustovoitov,Kehao Zhao,Megan Garfinkel,Adrian A. Canutescu,Roland L. Dunbrack,Peter D. Adams,Ronen Marmorstein +7 more
TL;DR: The crystal structure of an ASF1a–HIRA heterodimer and a biochemical dissection of ASF 1a's mutually exclusive interactions with HIRA and the p60 subunit of CAF-1 begin to define the molecular determinants of assembly of functionally diverse macromolecular histone chaperone complexes.
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Coupling of DNA Synthesis and Histone Synthesis in S Phase Independent of Cyclin/cdk2 Activity
David M. Nelson,Xiaofen Ye,Caitlin Hall,Hidelita Santos,Tianlin Ma,Gary D. Kao,Tim J. Yen,J. Wade Harper,Peter D. Adams +8 more
TL;DR: It is shown that ectopic expression of HIRA, the likely human ortholog of two cell cycle-regulated repressors of histone gene transcription in yeast, represses transcription of histones and that this, in turn, triggers a concerted block of DNA synthesis.
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Definition of pRB- and p53-Dependent and -Independent Steps in HIRA/ASF1a-Mediated Formation of Senescence-Associated Heterochromatin Foci
Xiaofen Ye,Brad Zerlanko,Rugang Zhang,Neeta Somaiah,Marc Lipinski,Paolo Salomoni,Peter D. Adams +6 more
TL;DR: Evidence indicates that downstream of HIRA's localization to PML bodies, the HIRA/ASF1a pathway cooperates with pRB and p53 to make SAHF, with the HI RA/ASf1a and pRB pathways acting in parallel.