P
Peter D. Adams
Researcher at University of Glasgow
Publications - 128
Citations - 20807
Peter D. Adams is an academic researcher from University of Glasgow. The author has contributed to research in topics: Senescence & Chromatin. The author has an hindex of 54, co-authored 115 publications receiving 17101 citations. Previous affiliations of Peter D. Adams include Discovery Institute & Fox Chase Cancer Center.
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Journal ArticleDOI
p53 status determines the role of autophagy in pancreatic tumour development
Mathias T. Rosenfeldt,Jim O'Prey,Jennifer P. Morton,Colin Nixon,Gillian M. Mackay,Agata Mrowinska,Amy Au,Taranjit Singh Rai,Liang Zheng,Rachel A. Ridgway,Peter D. Adams,Kurt I. Anderson,Eyal Gottlieb,Owen J. Sansom,Kevin M. Ryan +14 more
TL;DR: It is shown, in a humanized genetically-modified mouse model of pancreatic ductal adenocarcinoma (PDAC), that autophagy’s role in tumour development is intrinsically connected to the status of the tumour suppressor p53, and treatment with hydroxychloroquine significantly accelerates tumour formation in mice containing oncogenic Kras but lacking p53.
Journal ArticleDOI
Autophagy mediates degradation of nuclear lamina
Zhixun Dou,Caiyue Xu,Greg Donahue,Takeshi Shimi,Ji-An Pan,Jiajun Zhu,Andrejs Ivanov,Brian C. Capell,Adam M. Drake,Parisha P. Shah,Joseph M. Catanzaro,M. Daniel Ricketts,Trond Lamark,Stephen A. Adam,Ronen Marmorstein,Wei-Xing Zong,Terje Johansen,Robert D. Goldman,Peter D. Adams,Shelley L. Berger +19 more
TL;DR: The study suggests that this new function of autophagy acts as a guarding mechanism protecting cells from tumorigenesis, and prevents activated RAS-induced lamin B1 loss and attenuates oncogene-induced senescence in primary human cells.
Journal ArticleDOI
Mitochondria are required for pro‐ageing features of the senescent phenotype
Clara Correia-Melo,Clara Correia-Melo,Francisco D.M. Marques,Rhys Anderson,Graeme Hewitt,Rachael N. Hewitt,John J. Cole,Bernadette Carroll,Satomi Miwa,Jodie Birch,Alina Merz,Michael D. Rushton,Michelle Charles,Diana Jurk,Stephen W.G. Tait,Rafal Czapiewski,Laura C. Greaves,Glyn Nelson,Mohammad Bohlooly-Y,Sergio Rodriguez-Cuenca,Antonio Vidal-Puig,Derek A. Mann,Gabriele Saretzki,Giovanni Quarato,Douglas R. Green,Peter D. Adams,Thomas von Zglinicki,Viktor I. Korolchuk,João F. Passos +28 more
TL;DR: The results suggest that mitochondria are a candidate target for interventions to reduce the deleterious impact of senescence in ageing tissues.
Journal ArticleDOI
DNA methylation aging clocks: challenges and recommendations
Christopher G. Bell,Robert Lowe,Peter D. Adams,Peter D. Adams,Andrea A. Baccarelli,Stephan Beck,Jordana T. Bell,Brock C. Christensen,Vadim N. Gladyshev,Bastiaan T. Heijmans,Steve Horvath,Trey Ideker,Jean Pierre J. Issa,Karl T. Kelsey,Riccardo E. Marioni,Wolf Reik,Wolf Reik,Caroline L Relton,Leonard C. Schalkwyk,Andrew E. Teschendorff,Andrew E. Teschendorff,Wolfgang Wagner,Kang Zhang,Vardhman K. Rakyan +23 more
TL;DR: Key challenges to understand clock mechanisms and biomarker utility are discussed, including dissecting the drivers and regulators of age-related changes in single-cell, tissue- and disease-specific models, as well as exploring other epigenomic marks, longitudinal and diverse population studies, and non-human models.
Journal ArticleDOI
Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape
Parisha P. Shah,Greg Donahue,Gabriel L. Otte,Brian C. Capell,David M. Nelson,Kajia Cao,Varun Aggarwala,Hazel A Cruickshanks,Taranjit Singh Rai,Tony McBryan,Brian D. Gregory,Peter D. Adams,Shelley L. Berger +12 more
TL;DR: Comparing genome-wide Lys4 trimethylation on histone H3 and H3K27me3 distributions between proliferating and senescent human cells found dramatic differences in senescence, suggesting that pre-malignant senescent chromatin changes foreshadow epigenetic cancer changes.