Peter D. Adams

TL;DR: Whereas ultrasound treatment required to shear chromatin to within a range of 100–400 bp typically degrades large proteins, a combination of brief sonication and benzonase digestion allows for the generation of similarly sized chromatin fragments while preserving the integrity of associated proteins.

TL;DR: While both OIS and RS are associated with many common changes in gene expression compared to control proliferating cells, they also exhibit substantial differences, and these results are discussed in light of potential physiological consequences, tumor suppression and aging.

TL;DR: A summary of the initiators, pathways and roles of senescence are provided, as well as present examples ofSenescence and a possible use forsenescence in therapy.

TL;DR: It is proposed that the HIRA chaperone complex represses incoming naked viral DNAs through chromatinization as part of intrinsic cellular immunity.

TL;DR: It is revealed that the autophagy protein LC3/Atg8 directly interacts with the nuclear lamina protein LMNB1 (lamin B1), and binds to LMN/lamin-associated chromatin domains (LADs) through these interactions, which suggest that, in response to cancer-promoting stress, Autophagy degrades nuclear material to drive cellular senescence, as a means to restrain tumorigenesis.