Peter D. Adams

TL;DR: Data demonstrate that CABIN1 is a functional member of the human HUCA complex and so is the likely ortholog of yeast Hir3p, which is involved in heterochromatinization of the genome of senescent human cells.

TL;DR: It is found that secondary oncogene-induced senescence in vitro and in vivo requires Notch, rather than SASP alone, as previously thought, and global transcriptomic differences, a blunted SASP response, and the induction of fibrillar collagens in secondarysenescence point toward a functional diversification between secondary and primary senescences.

TL;DR: It is shown that primary human cells respond to a variety of small molecules that perturb DNA and histone modifications by recruiting HP1 proteins to sites of altered pericentromeric heterochromatin, which is essential to maintain the HP1-binding kinetochore protein hMis12 at Kinetochores and to suppress catastrophic mitotic defects.

TL;DR: A set of genes whose methylation and silencing in AML is reversed by DNA methyltransferase inhibitors are identified, and their reactivation byDNA methyl transferase inhibitors may contribute to therapeutic activity.