Roman Alpatov

TL;DR: It is shown that the JmjC-domain-containing related proteins UTX and JMJD3 catalyse demethylation of H3K27me3/2, which identifies a small family of H 3K27 demethylases with important, evolutionarily conserved roles in H3k27 methylation regulation and in animal anterior–posterior development.

TL;DR: These findings couple the function of BHC80 to that of LSD1, and indicate that unmodified H3K4 is part of the ‘histone code’, which raises the possibility that the generation and recognition of the unmodified state on histone tails in general might be just as crucial as post-translational modifications of histone for chromatin and transcriptional regulation.

TL;DR: In this article, the authors identify FMRP as a chromatin-binding protein that functions in the DNA damage response (DDR) and demonstrate that FMRPs participate in the DDR in a chromat-binding-dependent manner.

TL;DR: It is shown that nuclear FMRP occupies meiotic chromosomes and regulates the dynamics of the DDR machinery during mouse spermatogenesis and may impact gametogenesis and some developmental aspects of fragile X syndrome.

TL;DR: Evidence is presented that pinin/DRS interacts with the known transcriptional corepressor CtBP1 and Pnn was capable of relieving the Ct BP1-mediated repression of E-cadherin promoter activity and this interaction may reflect the existence of coupling factors involved in CtBP-mediated transcriptional regulation and mRNA processing events.