P
Peter G. Gibson
Researcher at University of Newcastle
Publications - 774
Citations - 53254
Peter G. Gibson is an academic researcher from University of Newcastle. The author has contributed to research in topics: Asthma & Sputum. The author has an hindex of 103, co-authored 711 publications receiving 45722 citations. Previous affiliations of Peter G. Gibson include University of Sydney & National Health and Medical Research Council.
Papers
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Journal ArticleDOI
Asthma exacerbations · 3: Pathogenesis
Peter A. B. Wark,Peter G. Gibson +1 more
TL;DR: Airway inflammation is a key part of the lower airway response in asthma exacerbation, and occurs together with airflow obstruction and increased airway responsiveness, the patterns of airway inflammation differ according to the trigger factor responsible for the exacerbation.
Journal ArticleDOI
Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes.
Katherine J. Baines,Katherine J. Baines,Jodie L. Simpson,Jodie L. Simpson,Lisa Wood,Lisa Wood,Rodney J. Scott,Naomi L. Fibbens,Naomi L. Fibbens,Heather Powell,Heather Powell,Douglas C. Cowan,D. Robin Taylor,Jan O. Cowan,Peter G. Gibson,Peter G. Gibson +15 more
TL;DR: In this article, a sputum gene expression signature of 6 biomarkers reproducibly and significantly discriminates inflammatory phenotypes of asthma and predicts inhaled corticosteroid (ICS) treatment response.
Journal ArticleDOI
Airway dysbiosis: Haemophilus influenzae and Tropheryma in poorly controlled asthma
Jodie L. Simpson,Joshua Daly,Katherine J. Baines,Ian A. Yang,John W. Upham,Paul N. Reynolds,Sandra Hodge,Sandra Hodge,Alan L. James,Philip Hugenholtz,Dana Willner,Peter G. Gibson +11 more
TL;DR: The sputum microbiome in adults with poorly controlled asthma was described and reduced bacterial diversity combined with a high prevalence of H. influenzae was observed in neutrophilic asthma, whereas eosinophilic asthma had abundant T. whipplei.
Journal ArticleDOI
Haemophilus influenzae infection drives IL-17-mediated neutrophilic allergic airways disease.
Ama-Tawiah Essilfie,Jodie L. Simpson,Jodie L. Simpson,Jay C. Horvat,Julie A. Preston,Margaret Dunkley,Paul S. Foster,Peter G. Gibson,Peter G. Gibson,Philip M. Hansbro +9 more
TL;DR: H. influenzae infection synergizes with AAD to induce Th17 immune responses that drive the development of neutrophilic and suppress eosinophilic inflammation during AAD, which results in a phenotype that is similar to neutrophobic asthma.
Journal ArticleDOI
A systematic evaluation of mechanisms in chronic cough.
Ian K. Carney,Peter G. Gibson,Keith Murree-Allen,Nicholas Saltos,Leslie G. Olson,Michael J. Hensley +5 more
TL;DR: It is concluded that chronic cough is a nonspecific symptom that is associated with several apparently unrelated mechanisms, including UAHR, somatization, BHR, and eosinophilic bronchitis.