Peter G. Gibson

TL;DR: The authors sought to investigate the detection of non‐eosinophilic asthma using induced sputum because this is an important subtype of clinical asthma, but its recognition is not standardized.

TL;DR: The only way to make progress in the future is to be much more clear about the meaning of the labels used for asthma and to acknowledge the assumptions associated with them, which are believed to be the most important causes of the stagnation in key clinical outcomes observed in the past 10 years.

TL;DR: This Perspective proposes a precision medicine strategy for chronic airway diseases in general, and asthma and COPD in particular, and a discussion of the concept of “treatable traits” as a way towards precision medicine of chronicAirway diseases.

TL;DR: If there are indeed two (or more) subtypes of asthma, and if non-eosinophilic (neutrophil mediated) asthma is relatively common, this would have major consequences for the treatment and Prevention of asthma since most treatment and prevention strategies are now almost entirely focused on allergic/eos inophilic asthma and allergen avoidance measures, respectively.

TL;DR: It is shown that feeding mice a high-fibre diet yields a distinctive gut microbiota, which increases the levels of the short-chain fatty acid, acetate, which led to marked suppression of allergic airways disease (AAD), by enhancing T-regulatory cell numbers and function.