R
Rachel E. Hardisty
Researcher at University of Nottingham
Publications - 9
Citations - 1303
Rachel E. Hardisty is an academic researcher from University of Nottingham. The author has contributed to research in topics: Mutagenesis (molecular biology technique) & Genome. The author has an hindex of 7, co-authored 9 publications receiving 1271 citations.
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Journal ArticleDOI
A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.
Patrick M. Nolan,Josephine Peters,Mark A. Strivens,Derek C. Rogers,Jim J. Hagan,Nigel K. Spurr,Ian C. Gray,Lucie Vizor,D Brooker,E Whitehill,R Washbourne,Tertius Hough,Simon Greenaway,M Hewitt,Xue Zhong Liu,Stefan L. McCormack,K Pickford,R Selley,Christine A. Wells,Zuzanna Tymowska-Lalanne,P. Roby,Peter H. Glenister,C Thornton,Caroline Thaung,J A Stevenson,Ruth M. Arkell,Philomena Mburu,Rachel E. Hardisty,Amy E. Kiernan,Alexandra Erven,Karen P. Steel,Stéphanie Voegeling,Jean-Louis Guénet,Carole D. Nickols,R Sadri,M Nasse,Adrian M. Isaacs,Kay E. Davies,M Browne,Elizabeth M. C. Fisher,Joanne E. Martin,Sohaila Rastan,Steve D.M. Brown,Jackie Hunter +43 more
TL;DR: A genome-wide, phenotype-driven screen for dominant mutations in the mouse is undertaken, which has led to a substantial increase in themouse mutant resource and represents a first step towards systematic studies of gene function in mammalian genetics.
Journal ArticleDOI
Defects in whirlin, a PDZ domain molecule involved in stereocilia elongation, cause deafness in the whirler mouse and families with DFNB31.
Philomena Mburu,Mirna Mustapha,Anabel Varela,Dominique Weil,Aziz El-Amraoui,Ralph H. Holme,Andreas Rump,Rachel E. Hardisty,Stéphane Blanchard,Roney S. Coimbra,Isabelle Perfettini,Nicholas J. Parkinson,Ann-Marie Mallon,Pete Glenister,Michael J. Rogers,Adam J.W. Paige,Lee Moir,Jo Clay,André Rosenthal,Xue Zhong Liu,Gonzalo Blanco,Karen P. Steel,Christine Petit,Steve D.M. Brown +23 more
TL;DR: These findings suggest that this novel PDZ domain–containing molecule acts as an organizer of submembranous molecular complexes that control the coordinated actin polymerization and membrane growth of stereocilia.
Journal ArticleDOI
The mouse slalom mutant demonstrates a role for Jagged1 in neuroepithelial patterning in the organ of Corti
Hsun Tsai,Rachel E. Hardisty,Charlotte R. Rhodes,Amy E. Kiernan,Phil Roby,Zuzanna Tymowska-Lalanne,Philomena Mburu,Sohaila Rastan,A. Jackie Hunter,Steve D. M. Brown,Karen P. Steel +10 more
TL;DR: A novel mouse mutant, slalom, is identified, which shows abnormalities in the patterning of hair cells in the organ of Corti and missing ampullae, structures that house the sensory epithelia of the semicircular canals.
Journal ArticleDOI
The deaf mouse mutant Jeff (Jf) is a single gene model of otitis media.
Rachel E. Hardisty,Alexandra Erven,Karen Logan,Susan Morse,Sylvia Guionaud,Sara Sancho–Oliver,A. Jackie Hunter,Steve D.M. Brown,Karen P. Steel +8 more
TL;DR: A novel deaf mouse mutant, Jeff (Jf), is identified as part of the UK mutagenesis program and should prove valuable in elucidating the underlying genetic pathways predisposing to otitis media.
Journal ArticleDOI
Mutagenesis strategies for identifying novel loci associated with disease phenotypes.
TL;DR: A number of approaches employing the chemical mutagen ethylnitrosourea (ENU) have been utilised by mouse geneticists to deliver a substantial new collection of mouse disease models.