Peter M. Rothwell

TL;DR: The risk of early recurrent stroke is highest in patients with large-artery atherosclerosis (LAA), which supports the need for urgent carotid imaging and prompt endarterectomy.

TL;DR: The authors discusses shortcomings of the usual blood pressure hypothesis, provides background to accompanying reports on the importance of blood pressure variability in prediction of risk of vascular events and in accounting for benefits of antihypertensive drugs, and draws attention to clinical implications and directions for future research.

TL;DR: The reported early risks of stroke after TIA were highly heterogeneous, but this could be largely accounted for by differences in study method, setting, and treatment, with lowest risks in studies of emergency treatment in specialist stroke services.

TL;DR: Drug-class effects on interindividual variation in blood pressure can account for differences in effects of antihypertensive drugs on risk of stroke independently of effects on mean SBP.

TL;DR: This article represents the update of ‘European Stroke Initiative Recommendations for Stroke Management’, first published in this Journal in 2000.