P
Peter Simmonds
Researcher at University of Oxford
Publications - 857
Citations - 69113
Peter Simmonds is an academic researcher from University of Oxford. The author has contributed to research in topics: Hepatitis C virus & Virus. The author has an hindex of 131, co-authored 823 publications receiving 62953 citations. Previous affiliations of Peter Simmonds include John Radcliffe Hospital & Edinburgh Royal Infirmary.
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Journal ArticleDOI
Treatment of hepatitis C infection in haemophiliacs: the Edinburgh experience.
TL;DR: A group of 32 patients are treated and response to interferon by ALT estimation and with a low-threshold semiquantitative polymerase chain reaction (PCR) to detect HCV RNA, and some of the preliminary results are given.
Posted ContentDOI
A vast world of viroid-like circular RNAs revealed by mining metatranscriptomes
Benjamin Lee,Uri Neri,Simon Roux,Yuri I. Wolf,Antonio P. Camargo,Mart Krupovic,Peter Simmonds,Nikos C. Kyrpides,Uri Gophna,Valerian V. Dolja,Eugene V. Koonin +10 more
TL;DR: A computational pipeline to identify viroid-like covalently closed circular (ccc) RNAs was developed and applied to 5,131 global metatranscriptomes and 1,344 plant transcriptomes and found numerous putative novel viroids, satellite RNAs, retrozymes, and ribozylike viruses.
Journal Article
Outbreak of acute hepatitis-c following intravenous immunoglobulin therapy
C. J. Healey,N. K. Sabharwal,F. McOmish,Roger W. Chapman,Kenneth A. Fleming,Peter Simmonds,Helen Chapel +6 more
Peer ReviewDOI
Author response: RNA virus attenuation by codon pair deoptimisation is an artefact of increases in CpG/UpA dinucleotide frequencies
Journal ArticleDOI
Failure to Detect Hepatitis A Virus RNA in Factor VIII Concentrates Using the Polymerase Chain Reaction: Results of a Preliminary Study
F. McOmish,F. McOmish,Peng Lee Yap,Peng Lee Yap,H. H. Hart,H. H. Hart,K Peerlinck,K Peerlinck,S. M. Burns,S. M. Burns,Peter Simmonds,Peter Simmonds +11 more
TL;DR: The preliminary results suggest that either the contamination of factor VIII concentrates by HAV RNA is an extremely rare event or the PCR is insufficiently sensitive to detect an infective HAV dose since each batch offactor VIII concentrate would have been derived from a plasma pool consisting of 10,000 donations, or more and the resulting concentration of virus may be 102 or less.