Peter Simmonds

TL;DR: A role for the circadian clock component REV-ERBα in regulating flavivirus replication is highlighted, as it affects entry of hepatitis C virus into hepatocytes and genome replication of HCV and related flaviviruses dengue and zika.

TL;DR: In this article, the Scripps Institution of Oceanography (SIO) 1993 absolute calibration scale is used, reducing the concentrations by a factor of 0.77 compared to previous ALE/GAGE reports.

TL;DR: Genotypes ofHCV Hepatitis C virus (HCV) has been identified as the main causative agent of post-transfusion non-A, non-B hepatitis, and recent analyses indicate that the current genotypes of HCV evolved from a common ancestor at least 500-2000 years ago.

TL;DR: Although blood donors are not representative of the overall population, it is demonstrated that serosurveys of blood banks can serve as a useful tool for tracking the emergence and progression of an epidemic such as the SARS-CoV-2 outbreak.

TL;DR: Plasma-derived CFC are now judged safe in terms of many known infectious agents, including hepatitis B and C viruses, HIV, and human T-cell lymphotropic virus, but emerging pathogens could pose future threats, particularly those with blood-borne stages that are resistant to viral-inactivation steps in the manufacturing process, such as non-lipid-coated viruses.