P
Petrine Wellendorph
Researcher at University of Copenhagen
Publications - 100
Citations - 2883
Petrine Wellendorph is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Receptor & GABAA receptor. The author has an hindex of 27, co-authored 83 publications receiving 2573 citations. Previous affiliations of Petrine Wellendorph include University of Turin & ACADIA Pharmaceuticals Inc..
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Journal ArticleDOI
Structure, Pharmacology and Therapeutic Prospects of Family C G-Protein Coupled Receptors
TL;DR: Cinacalcet is the first allosteric GPCR modulator to enter the market, which demonstrates that the therapeutic principle of allosterics modulation can also be extended to this important drug target class.
Journal ArticleDOI
Deorphanization of GPRC6A: A Promiscuous l-α-Amino Acid Receptor with Preference for Basic Amino Acids
Petrine Wellendorph,Kasper B. Hansen,Anders Balsgaard,Jeremy R. Greenwood,Jan Egebjerg,Hans Bräuner-Osborne +5 more
TL;DR: The utility of a chimeric receptor approach in combination with molecular modeling, for elucidating agonist interaction with GPRC6A, a novel family C G-protein-coupled receptor, is demonstrated.
Journal ArticleDOI
Specific γ-hydroxybutyrate-binding sites but loss of pharmacological effects of γ-hydroxybutyrate in GABAB(1)-deficient mice
Klemens Kaupmann,John F. Cryan,Petrine Wellendorph,Cedric Mombereau,Gilles Sansig,Klaus Klebs,Markus Schmutz,Wolfgang Froestl,Herman van der Putten,Johannes Mosbacher,Hans Bräuner-Osborne,Peter C. Waldmeier,Bernhard Bettler +12 more
TL;DR: It appears that all studied GHB effects are GABAB receptor dependent, and the GHB‐induced GTPγ[35S] responses are mediated by GABAB receptors.
Journal ArticleDOI
Molecular pharmacology of promiscuous seven transmembrane receptors sensing organic nutrients.
TL;DR: The ligand-receptor interactions of the promiscuous receptors of organic nutrients thus remain an interesting subject of emerging functional importance.
Journal ArticleDOI
Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor.
TL;DR: This work reports the existence of two additional GPRC6A isoforms (2 and 3) carrying in-frame deletions in the ATD, and confirms that isoforms 2 and 3 are naturally occurring splice variants.