P
Petteri Hintsanen
Researcher at University of Helsinki
Publications - 16
Citations - 772
Petteri Hintsanen is an academic researcher from University of Helsinki. The author has contributed to research in topics: Phosphoproteomics & Subgraph isomorphism problem. The author has an hindex of 12, co-authored 16 publications receiving 590 citations. Previous affiliations of Petteri Hintsanen include Helsinki Institute for Information Technology.
Papers
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Journal ArticleDOI
Making sense of large-scale kinase inhibitor bioactivity data sets: a comparative and integrative analysis.
Jing Tang,Agnieszka Szwajda,Sushil Kumar Shakyawar,Tao Xu,Petteri Hintsanen,Krister Wennerberg,Tero Aittokallio +6 more
TL;DR: A systematic evaluation of target selectivity profiles across three recent large-scale biochemical assays of kinase inhibitors and further compared these standardized bioactivity assays with data reported in the widely used databases ChEMBL and STITCH revealed relative benefits and potential limitations among the bioactivity types.
Book ChapterDOI
Link discovery in graphs derived from biological databases
TL;DR: In this paper, the authors propose a method for link discovery in biological databases, i.e., for prediction and evaluation of implicit or previously unknown connections between biological entities and concepts, and propose measures for link goodness that are based on three factors: edge reliability, relevance, and rarity.
Journal ArticleDOI
Finding reliable subgraphs from large probabilistic graphs
Petteri Hintsanen,Hannu Toivonen +1 more
TL;DR: Two new heuristics for solving the most reliable subgraph extraction problem on large, undirected probabilistic graphs are proposed and results indicate that the methods scale much better to large input graphs, both computationally and in terms of the quality of the result.
Journal ArticleDOI
Phosphoproteomics to Characterize Host Response During Influenza A Virus Infection of Human Macrophages
Sandra Söderholm,Denis E. Kainov,Tiina Öhman,Oxana V. Denisova,Bert Schepens,Evgeny Kulesskiy,Susumu Y. Imanishi,Garry L. Corthals,Petteri Hintsanen,Tero Aittokallio,Xavier Saelens,Sampsa Matikainen,Tuula A. Nyman +12 more
TL;DR: The first comprehensive phosphoproteome characterization of influenza A virus infection in primary human macrophages is provided, and evidence that cyclin-dependent kinases represent potential therapeutic targets for more effective treatment of influenza infections is provided.
Journal ArticleDOI
Systematic Identification of MicroRNAs That Impact on Proliferation of Prostate Cancer Cells and Display Changed Expression in Tumor Tissue
Anna Aakula,Anna Aakula,Anna Aakula,Pekka Kohonen,Suvi-Katri Leivonen,Rami Mäkelä,Petteri Hintsanen,John-Patrick Mpindi,Elena S. Martens-Uzunova,Tero Aittokallio,Guido Jenster,Merja Perälä,Olli Kallioniemi,Olli Kallioniemi,Päivi Östling,Päivi Östling +15 more
TL;DR: Novel regulatory molecules are identified, which impact on PCa proliferation and are aberrantly expressed in clinical tumors, which reveals regulatory nodes with potential for therapy.