Phil Chapman

TL;DR: The discovery of GSK3685032 is reported, a potent first-in-class DNMT1-selective inhibitor that was shown via crystallographic studies to compete with the active-site loop ofDNMT1 for penetration into hemi-methylated DNA between two CpG base pairs.

TL;DR: The MultiAssayExperiment Bioconductor package reduces major obstacles to efficient, scalable, and reproducible statistical analysis of multiomics data and enhances data science applications of multiple omics datasets.

TL;DR: It is suggested that reduced Egr-1 gene expression may contribute to decreased beta-cell proliferation and the consequent beta- cell failure observed in the later stages of type 2 diabetes.

TL;DR: It is highlighted that cross-referencing between genomic databases is required to comprehensively assess genomic alterations in commonly used cell lines and that there are still significant opportunities to identify novel drivers of tumorigenesis in poorly sequenced areas of the exome.

TL;DR: Acting to restore the function of MLK4 selectively induced the JNK pathway and its downstream targets, cJUN, ATF3, and the cyclin-dependent kinase inhibitors CDKN1A and CDKN2B found that it reduced cell viability, proliferation, and colony formation in vitro and delayed tumor growth in vivo.