P
Phil Sanders
Researcher at University of Barcelona
Publications - 6
Citations - 350
Phil Sanders is an academic researcher from University of Barcelona. The author has contributed to research in topics: Induced pluripotent stem cell & Progenitor cell. The author has an hindex of 5, co-authored 6 publications receiving 279 citations.
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Journal ArticleDOI
Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice
Ryan G. Lim,Lisa Salazar,D Wilton,Alvin R. King,Jennifer Stocksdale,Delaram Sharifabad,Alice L Lau,Beth Stevens,Jack C. Reidling,Sara T. Winokur,Malcolm Casale,Leslie M. Thompson,Mónica Pardo,A Gerardo García Díaz-Barriga,Marco Straccia,Phil Sanders,Jordi Alberch,Josep M. Canals,Julia A. Kaye,Mariah Dunlap,Lisa Jo,Hanna May,Elliot Mount,Cliff Anderson-Bergman,Kelly Haston,Steven Finkbeiner,Amanda J. Kedaigle,Theresa A. Gipson,Ferah Yildirim,Christopher W. Ng,Pamela Milani,David E. Housman,Ernest Fraenkel,Nicholas D. Allen,Paul J. Kemp,Ranjit Singh Atwal,Marta Biagioli,James F. Gusella,Marcy E. MacDonald,Sergey S Akimov,Nicolas Arbez,Jacqueline Stewart,Christopher A. Ross,Virginia B. Mattis,Colton M Tom,Loren Ornelas,Anais Sahabian,Lindsay Lenaeus,Berhan Mandefro,Dhruv Sareen,Clive N. Svendsen +50 more
TL;DR: The data suggest that mutant huntingtin impairs neurodevelopmental pathways that could disrupt synaptic homeostasis and increase vulnerability to the pathologic consequence of expanded polyglutamine repeat-associated phenotypes in neural cells and of cognitive impairment and synaptic pathology in HD model R6/2 mice.
Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice
Ryan G. Lim,Lisa Salazar,D Wilton,Alvin R. King,Jennifer Stocksdale,Delaram Sharifabad,L Alice Lau,Beth Stevens,Jack C. Reidling,Sara T. Winokur,Malcolm Casale,Leslie M. Thompson,Mónica Pardo,A Gerardo García Díaz-Barriga,Marco Straccia,Phil Sanders,Jordi Alberch,Josep M. Canals,Julia A. Kaye,Mariah Dunlap,Lisa Jo,Hanna May,Elliot Mount,Cliff Anderson-Bergman,Kelly Haston,Steven Finkbeiner,Nicholas D. Allen,Paul J. Kemp,Ranjit Singh Atwal,Marta Biagioli,James F. Gusella,Marcy E. MacDonald,Sergey S Akimov,Nicolas Arbez,Jacqueline Stewart,Christopher A. Ross,Virginia B. Mattis,Colton M Tom,Loren Ornelas,Anais Sahabian,Lindsay Lenaeus,Berhan Mandefro,Dhruv Sareen,Clive N. Svendsen,Amanda J. Kedaigle,Theresa Anne Wasylenko,Ferah Yildirim,Christopher W. Ng,Pamela Milani,David E. Housman,Ernest Fraenkel +50 more
Journal ArticleDOI
RTP801 Is Involved in Mutant Huntingtin-Induced Cell Death.
Núria Martín-Flores,Joan Romaní-Aumedes,Laura Rué,Mercè Canal,Phil Sanders,Marco Straccia,Nicholas D. Allen,Jordi Alberch,Josep M. Canals,Esther Pérez-Navarro,Cristina Malagelada +10 more
TL;DR: The results suggest that RTP801 is a novel downstream effector of mhtt-induced toxicity and that it may be relevant to the human disease.
Journal ArticleDOI
Quantitative high-throughput gene expression profiling of human striatal development to screen stem cell–derived medium spiny neurons
Marco Straccia,Gerardo García-Díaz Barriga,Phil Sanders,Georgina Bombau,Jordi Carrere,Pedro Belio Mairal,Ngoc-Nga Vinh,Sun Yung,Claire Kelly,Clive N. Svendsen,Paul J. Kemp,Jamshid Arjomand,Ryan C. Schoenfeld,Jordi Alberch,Nicholas D. Allen,Anne Elizabeth Rosser,Josep M. Canals +16 more
TL;DR: This work defines by a quantitative high-throughput gene expression analysis the subset of specific genes of the whole ganglionic eminence (WGE) and adult human striatum and next used these gene profiles to characterize the differentiation of hPSCs.
Journal ArticleDOI
Human Pluripotent Stem Cell-Derived Neurons Are Functionally Mature In Vitro and Integrate into the Mouse Striatum Following Transplantation
Andrea Comella-Bolla,Javier G. Orlandi,Javier G. Orlandi,Javier G. Orlandi,Andrés Miguez,Marco Straccia,María García-Bravo,Georgina Bombau,Mireia Galofré,Phil Sanders,Jordi Carrere,José C. Segovia,Joan Blasi,Nicholas D. Allen,Jordi Alberch,Jordi Soriano,Josep M. Canals +16 more
TL;DR: The findings demonstrate the potential of this robust human neuronal differentiation protocol, which will bring new opportunities for the study of human neurodevelopment and neurodegeneration, and will open new avenues in cell-based therapies, pharmacological studies and alternative in vitro toxicology.