P
Pia Ostergaard
Researcher at St George's, University of London
Publications - 55
Citations - 2921
Pia Ostergaard is an academic researcher from St George's, University of London. The author has contributed to research in topics: Primary lymphedema & Lymphatic system. The author has an hindex of 22, co-authored 51 publications receiving 2363 citations. Previous affiliations of Pia Ostergaard include Natural History Museum & St George's Hospital.
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Journal ArticleDOI
Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome)
Pia Ostergaard,Michael A. Simpson,Fiona Connell,Colin G. Steward,Glen Brice,Wesley J. Woollard,Dimitra Dafou,Tatjana Kilo,Sarah F. Smithson,Peter Lunt,Victoria Murday,Shirley Hodgson,Russell Keenan,Daniela T. Pilz,Ines Martinez-Corral,Taija Makinen,Peter S. Mortimer,Steve Jeffery,Richard C. Trembath,Sahar Mansour +19 more
TL;DR: It is indicated that haploinsufficiency of GATA2 underlies primary lymphedema and predisposes to acute myeloid leukemia in Emberger syndrome.
Journal ArticleDOI
The phylogeny of the Schistosomatidae based on three genes with emphasis on the interrelationships of Schistosoma Weinland, 1858.
Anne E. Lockyer,Peter D. Olson,Pia Ostergaard,David Rollinson,David A. Johnston,S. W. Attwood,Vr Southgate,Petr Horák,S. D. Snyder,Thanh Hoa Le,Takeshi Agatsuma,Donald P. McManus,A. C. Carmichael,S. Naem,D. T. J. Littlewood +14 more
TL;DR: The principal findings are that Ornithobilharzia and AustrobilHarzia form a sister group to the Schistosoma; mammalian schistosomes appear paraphyletic and 2 TrichobilharZia species, T. ocellata and T. szidati, seem to be synonymous.
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Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis.
Elisavet Fotiou,Silvia Martin-Almedina,Michael A. Simpson,Shin Lin,Kristiana Gordon,Glen Brice,Giles Atton,Iona Jeffery,David C. Rees,Cyril Mignot,Julie Vogt,Tessa Homfray,Michael Snyder,Stanley G. Rockson,Steve Jeffery,Peter S. Mortimer,Sahar Mansour,Pia Ostergaard +17 more
TL;DR: Findings indicate that PIEZO1 is also involved in the development of lymphatic structures, and this work reports an autosomal recessive form of GLD with a high incidence of non-immune hydrops fetalis and childhood onset of facial and four limb lymphoedema.
Journal ArticleDOI
Lipedema: an inherited condition.
Anne H. Child,Kristiana Gordon,Pip Sharpe,Glen Brice,Pia Ostergaard,Steve Jeffery,Peter S. Mortimer +6 more
TL;DR: It is proposed that lipedema is a genetic condition with either X‐linked dominant inheritance or more likely, autosomal dominant inheritance with sex limitation, and appears to be a condition almost exclusively affecting females, presumably estrogen‐requiring as it usually manifests at puberty.
Journal ArticleDOI
Mutation in Vascular Endothelial Growth Factor-C, a Ligand for Vascular Endothelial Growth Factor Receptor-3, Is Associated With Autosomal Dominant Milroy-Like Primary Lymphedema
Kristiana Gordon,Dörte Schulte,Glen Brice,Michael A. Simpson,M. Guy Roukens,Andreas van Impel,Fiona Connell,Kamini Kalidas,Steve Jeffery,Peter S. Mortimer,Sahar Mansour,Stefan Schulte-Merker,Pia Ostergaard +12 more
TL;DR: In this paper, a frameshift variant, c.571_572insTT in VEGFC, was identified in 1 proband, and the variant cosegregated with the affected status in the family.