P
Pier G. Mastroberardino
Researcher at Erasmus University Medical Center
Publications - 68
Citations - 4248
Pier G. Mastroberardino is an academic researcher from Erasmus University Medical Center. The author has contributed to research in topics: Mitochondrion & DNA damage. The author has an hindex of 30, co-authored 62 publications receiving 3684 citations. Previous affiliations of Pier G. Mastroberardino include University of Rome Tor Vergata & University of L'Aquila.
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Journal ArticleDOI
AIF deficiency compromises oxidative phosphorylation
Nicola Vahsen,Céline Candé,Jean Briere,Paule Bénit,Nicholas Joza,Nathanael Larochette,Pier G. Mastroberardino,Marie O. Pequignot,Noelia Casares,Vladimir Lazar,Olivier Feraud,Najet Debili,Silke Wissing,Silvia Engelhardt,Frank Madeo,Mauro Piacentini,Josef M. Penninger,Hermann Schägger,Pierre Rustin,Guido Kroemer +19 more
TL;DR: It is shown that human or mouse cells lacking AIF as a result of homologous recombination or small interfering RNA exhibit high lactate production and enhanced dependency on glycolytic ATP generation, due to severe reduction of respiratory chain complex I activity.
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N-Terminal Mutant Huntingtin Associates with Mitochondria and Impairs Mitochondrial Trafficking
Adam L. Orr,Shihua Li,Chuan-En Wang,He Li,Jianjun Wang,Juan Rong,Xingshun Xu,Pier G. Mastroberardino,J. Timothy Greenamyre,Xiao-Jiang Li +9 more
TL;DR: It is demonstrated that specific N-terminal mutant htt fragments associate with mitochondria in Hdh(CAG)150 knock-in mouse brain and that this association increases with age, suggesting that this interaction may be a novel target for therapeutic strategies in HD.
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Intersecting pathways to neurodegeneration in Parkinson's disease: Effects of the pesticide rotenone on DJ-1, α-synuclein, and the ubiquitin–proteasome system
Ranjita Betarbet,Rosa M. Canet-Avilés,Todd B. Sherer,Pier G. Mastroberardino,Chris McLendon,Jin Ho Kim,Serena Lund,Hye-Mee Na,Georgia Taylor,Neil F. Bence,Ron R. Kopito,Byoung Boo Seo,Takao Yagi,Akemi Yagi,Gary R. Klinefelter,Mark R. Cookson,J. Timothy Greenamyre +16 more
TL;DR: Chronic exposure to a pesticide and mitochondrial toxin brings into play three systems, DJ-1, alpha-synuclein, and the ubiquitin-proteasome system, and implies that mitochondrial dysfunction and oxidative stress link environmental and genetic forms of the disease.
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Transglutaminase 2-/- mice reveal a phagocytosis-associated crosstalk between macrophages and apoptotic cells.
Zsuzsa Szondy,Zsolt Sarang,Peter Molnar,Tamás Németh,Mauro Piacentini,Pier G. Mastroberardino,Laura Falasca,Daniel Aeschlimann,Judit Kovács,Ildikó Kiss,Eva Szegezdi,Gabriella Lakos,Éva Rajnavölgyi,Paul J Birckbichler,Gerry Melino,Gerry Melino,László Fésüs +16 more
TL;DR: It is reported that apoptosis could be induced in TGase2-/- mice; however, the clearance of apoptotic cells was defective during the involution of thymus elicited by dexamethasone, anti-CD3 antibody, or γ-irradiation, and in the liver after induced hyperplasia.
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Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia.
Noemi A. Zambetti,Zhen Ping,Si Chen,Keane Jared Guillaume Kenswil,Maria Athina Mylona,Mathijs A. Sanders,Remco Hoogenboezem,Eric Bindels,Maria Niken Adisty,Paulina M. H. van Strien,Cindy S. van der Leije,Theresia M. Westers,Eline M. P. Cremers,Chiara Milanese,Pier G. Mastroberardino,Johannes P.T.M. van Leeuwen,Bram C. J. van der Eerden,Ivo P. Touw,Taco W. Kuijpers,Roland Kanaar,Arjan A. van de Loosdrecht,Thomas Vogl,Marc H.G.P. Raaijmakers +22 more
TL;DR: P perturbation of mesenchymal cells in a mouse model of the pre-leukemic disorder Shwachman-Diamond syndrome induces mitochondrial dysfunction, oxidative stress, and activation of DNA damage responses in hematopoietic stem and progenitor cells.