O
Olivier Chassande
Researcher at University of Bordeaux
Publications - 74
Citations - 5192
Olivier Chassande is an academic researcher from University of Bordeaux. The author has contributed to research in topics: Thyroid hormone receptor & Thyroid. The author has an hindex of 39, co-authored 74 publications receiving 4880 citations. Previous affiliations of Olivier Chassande include Centre national de la recherche scientifique & École normale supérieure de Lyon.
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Journal ArticleDOI
In vitro differentiation of embryonic stem cells into glial cells and functional neurons.
TL;DR: Evidence is provided that embryonic stem cells can differentiate first into neuron-glia progenitors, and later into glial cells and functional neurons, in vitro.
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Different functions for the thyroid hormone receptors TRα and TRβ in the control of thyroid hormone production and post‐natal development
Karine Gauthier,Olivier Chassande,Michela Plateroti,Jean-Paul Roux,Claude Legrand,Bertrand Pain,Bernard Rousset,Roy E. Weiss,Jacqueline Trouillas,Jacques Samarut +9 more
TL;DR: It is shown by this method that the TRβ receptors are the most potent regulators of the production of thyroid stimulating hormone (TSH), and that redundancy is only partial and concerns a limited number of functions.
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The T3Rα gene encoding a thyroid hormone receptor is essential for post‐natal development and thyroid hormone production
A. Fraichard,Olivier Chassande,Michelina Plateroti,Jean-Paul Roux,Jacqueline Trouillas,Colette Dehay,Claude Legrand,Karine Gauthier,Michèle Kedinger,Luc Malaval,Bernard Rousset,Jacques Samarut +11 more
TL;DR: The abnormal phenotypes observed on the homozygous mutant mice strongly suggest that the T3Rα gene is essential for the transformation of a mother‐dependent pup to an ‘adult’ mouse.
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Genetic Analysis Reveals Different Functions for the Products of the Thyroid Hormone Receptor α Locus
Karine Gauthier,Michelina Plateroti,Clare B. Harvey,Graham R. Williams,Roy E. Weiss,Samuel Refetoff,James F. Willott,Victoria Sundin,Jean-Paul Roux,Luc Malaval,Masahiro Hara,Jacques Samarut,Olivier Chassande +12 more
TL;DR: It is demonstrated that the TRΔα protein isoforms, which are natural products of the TRα locus, are the key determinants of these phenotypical differences.
Journal ArticleDOI
Cardiac ion channel expression and contractile function in mice with deletion of thyroid hormone receptor alpha or beta.
Bernd Gloss,Susanne U. Trost,Wolfgang F. Bluhm,Eric Swanson,Robert B. Clark,Robert J. Winkfein,Kathryn M. Janzen,Wayne R. Giles,Olivier Chassande,Jacques Samarut,Wolfgang H. Dillmann +10 more
TL;DR: Findings indicate that potassium channel genes that code for K+ channels involved in action potential repolarization, like KV 4.2 and minK, are T3Rα targets and cyclic nucleotide-gated channels, HCN2 and HCN4, are targets of T2Rα, and these transcripts respond markedly to altered T3 signaling concomitant with bradycardia.