P
Ping Liu
Researcher at Chinese Academy of Sciences
Publications - 7
Citations - 368
Ping Liu is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Receptor & 5-HT receptor. The author has an hindex of 4, co-authored 7 publications receiving 242 citations.
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Journal ArticleDOI
Cryo-EM structure of human rhodopsin bound to an inhibitory G protein
Yanyong Kang,Oleg Kuybeda,Parker W. de Waal,Somnath Mukherjee,Ned Van Eps,Przemysław Dutka,Przemysław Dutka,X. Edward Zhou,Alberto Bartesaghi,Satchal K. Erramilli,Takefumi Morizumi,Xin Gu,Yanting Yin,Ping Liu,Yi Jiang,Xing Meng,Gongpu Zhao,Karsten Melcher,Oliver P. Ernst,Anthony A. Kossiakoff,Sriram Subramaniam,H. Eric Xu,H. Eric Xu +22 more
TL;DR: It is shown that the major interactions between activated rhodopsin and Gi are mediated by the C-terminal helix of the Gi α-subunit, which is wedged into the cytoplasmic cavity of the transmembrane helix bundle and directly contacts the amino terminus of helix 8 of rhodopin.
Journal ArticleDOI
Crystal structure of the human 5-HT1B serotonin receptor bound to an inverse agonist.
Wanchao Yin,X. Edward Zhou,X. Edward Zhou,Dehua Yang,Parker W. de Waal,Meitian Wang,Antao Dai,Xiaoqing Cai,Chia-Ying Huang,Ping Liu,Xiaoxi Wang,Yanting Yin,Yanting Yin,Bo Liu,Yu Zhou,Jiang Wang,Hong Liu,Martin Caffrey,Karsten Melcher,Yechun Xu,Ming-Wei Wang,H. Eric Xu,H. Eric Xu,Yi Jiang,Yi Jiang +24 more
TL;DR: The inverse agonist-bound 5-HT1BR structure provides a structural understanding of the inactivation mechanism of 5- HT1BR and some other class A GPCRs, characterized by ligand-induced outward movement of the extracellular end of TM6 that is coupled with inward move of the cytoplasmic end of this helix.
Journal ArticleDOI
The structural basis of the dominant negative phenotype of the Gαi1β1γ2 G203A/A326S heterotrimer.
Ping Liu,Ming-zhu Jia,X. Edward Zhou,Parker W. de Waal,Bradley M. Dickson,Bo Liu,Li Hou,Yanting Yin,Yanyong Kang,Yi Shi,Karsten Melcher,H. Eric Xu,H. Eric Xu,Yi Jiang +13 more
TL;DR: The results suggest that the mutations impede guanine nucleotide binding and Gα-Gβγ protein dissociation and favor the formation of the G protein/GPCR complex, thus blocking signal propagation.
ComponentDOI
The structural basis of the dominant negative phenotype of the G alpha i1 beta 1 gamma 2 G203A/A326S heterotrimer
Ping Liu,M.-Z Jia,X.E. Zhou,P.W De Waal,Bradley M. Dickson,Bo Liu,Li Hou,Yu-Ling Yin,Yanyong Kang,Yi Shi,Karsten Melcher,H.E. Xu,Yi Jiang +12 more
Journal ArticleDOI
Ligand-induced activation of ERK1/2 signaling by constitutively active G(s)-coupled 5-HT receptors
Ping Liu,Yu-Ling Yin,Ting Wang,Ting Wang,Li Hou,Xiaoxi Wang,Man Wang,Guanguan Zhao,Yi Shi,H. Eric Xu,Yi Jiang +10 more
TL;DR: It is found that the phosphorylation and activation of ERK1/2 are ligand-induced, in contrast to the constitutively active Gs signaling, which indicates that Gs signaled alone is not sufficient for ERK 1/2 activation in these three 5-HT receptors.