K
Karsten Melcher
Researcher at Van Andel Institute
Publications - 132
Citations - 11154
Karsten Melcher is an academic researcher from Van Andel Institute. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 44, co-authored 127 publications receiving 8341 citations. Previous affiliations of Karsten Melcher include University of Toronto & Chinese Academy of Sciences.
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Journal ArticleDOI
Amyloid beta: structure, biology and structure-based therapeutic development
Guo Fang Chen,Ting-Hai Xu,Yan Yan,Yu Ren Zhou,Yi Jiang,Karsten Melcher,H. Eric Xu,H. Eric Xu +7 more
TL;DR: The structures, biological functions, and neurotoxicity role of Aβ are reviewed, the potential receptors that interact with Aβ and mediate Aβ intake, clearance, and metabolism are discussed, and the therapeutic developments and recent advances of different strategies for treating Alzheimer's disease are summarized.
Journal ArticleDOI
Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
Yanyong Kang,X. Edward Zhou,Xiang Gao,Yuanzheng He,Wei Liu,Andrii Ishchenko,Anton Barty,Thomas A. White,Oleksandr Yefanov,Gye Won Han,Qingping Xu,Parker W. de Waal,Jiyuan Ke,M. H. Eileen Tan,Chenghai Zhang,Arne Moeller,Graham M. West,Bruce D. Pascal,Ned Van Eps,Lydia N. Caro,Sergey A. Vishnivetskiy,Regina J. Lee,Kelly Suino-Powell,Xin Gu,Kuntal Pal,Jinming Ma,Xiaoyong Zhi,Sébastien Boutet,Garth J. Williams,Marc Messerschmidt,Cornelius Gati,Nadia A. Zatsepin,Dingjie Wang,Daniel James,Shibom Basu,Shatabdi Roy-Chowdhury,Chelsie E. Conrad,Jesse Coe,Haiguang Liu,Stella Lisova,Christopher Kupitz,Ingo Grotjohann,Raimund Fromme,Yi Jiang,Minjia Tan,Huaiyu Yang,Jun Li,Meitian Wang,Zhong Zheng,Dianfan Li,Nicole Howe,Yingming Zhao,Jörg Standfuss,Kay Diederichs,Yuhui Dong,Clinton S. Potter,Bridget Carragher,Martin Caffrey,Hualiang Jiang,Henry N. Chapman,John C. H. Spence,Petra Fromme,Uwe Weierstall,Oliver P. Ernst,Vsevolod Katritch,Vsevolod V. Gurevich,Patrick R. Griffin,Wayne L. Hubbell,Raymond C. Stevens,Vadim Cherezov,Karsten Melcher,H. Eric Xu +71 more
TL;DR: The crystal structure of a constitutively active form of human rhodopsin bound to a pre-activated form of the mouse visual arrestin is determined by serial femtosecond X-ray laser crystallography and provides a basis for understanding GPCR-mediated arrestin-biased signalling.
Journal ArticleDOI
DWARF 53 acts as a repressor of strigolactone signalling in rice
Liang Jiang,Xue Liu,Guosheng Xiong,Huihui Liu,Fulu Chen,Lei Wang,Xiangbing Meng,Guifu Liu,Hong Yu,Yundong Yuan,Wei Yi,Lihua Zhao,Honglei Ma,Yuanzheng He,Wu Zhongshan,Karsten Melcher,Qian Qian,H. Eric Xu,Yonghong Wang,Jiayang Li +19 more
TL;DR: The characterization of a dominant SL-insensitive rice (Oryza sativa) mutant dwarf 53 (d53) and the cloning of D53, which encodes a substrate of the SCFD3 ubiquitination complex and functions as a repressor of SL signalling are reported.
Journal ArticleDOI
Androgen receptor: structure, role in prostate cancer and drug discovery
TL;DR: An overview of androgen receptor structure and activity, its actions in prostate cancer, and how structural information and high-throughput screening have been or can be used for drug discovery are provided are provided.
Journal ArticleDOI
A gate–latch–lock mechanism for hormone signalling by abscisic acid receptors
Karsten Melcher,L.-M. Ng,L.-M. Ng,X. Edward Zhou,F.-F. Soon,F.-F. Soon,Yong Xu,Kelly Suino-Powell,Sang-Youl Park,Joshua J. Weiner,Hiroaki Fujii,Hiroaki Fujii,Viswanathan Chinnusamy,Viswanathan Chinnusamy,Amanda Kovach,Jun-Jun Li,Jun-Jun Li,Yonghong Wang,Jiayang Li,Francis C. Peterson,Davin R. Jensen,Eu Leong Yong,Brian F. Volkman,Sean R. Cutler,Jian-Kang Zhu,Jian-Kang Zhu,H. Eric Xu +26 more
TL;DR: In this paper, crystal structures of apo and ABA-bound receptors as well as a ternary PYL2-ABA-PP2C complex were reported, showing that apo receptors contain an open ligand-binding pocket flanked by a gate that closes in response to ABA by way of conformational changes in two highly conserved beta-loops.