Y
Yi Jiang
Researcher at Chinese Academy of Sciences
Publications - 64
Citations - 5725
Yi Jiang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 23, co-authored 59 publications receiving 3972 citations. Previous affiliations of Yi Jiang include Van Andel Institute & Scripps Research Institute.
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Journal ArticleDOI
Amyloid beta: structure, biology and structure-based therapeutic development
Guo Fang Chen,Ting-Hai Xu,Yan Yan,Yu Ren Zhou,Yi Jiang,Karsten Melcher,H. Eric Xu,H. Eric Xu +7 more
TL;DR: The structures, biological functions, and neurotoxicity role of Aβ are reviewed, the potential receptors that interact with Aβ and mediate Aβ intake, clearance, and metabolism are discussed, and the therapeutic developments and recent advances of different strategies for treating Alzheimer's disease are summarized.
Journal ArticleDOI
Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation.
TL;DR: The results show that p38 may influence host defence and inflammation by maintaining the balance of c-Jun protein consumed during infection, and a link between the p38 pathway and a member of the myocyte-enhancer factor 2 (MEF2) group of transcription factors is demonstrated.
Journal ArticleDOI
Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
Yanyong Kang,X. Edward Zhou,Xiang Gao,Yuanzheng He,Wei Liu,Andrii Ishchenko,Anton Barty,Thomas A. White,Oleksandr Yefanov,Gye Won Han,Qingping Xu,Parker W. de Waal,Jiyuan Ke,M. H. Eileen Tan,Chenghai Zhang,Arne Moeller,Graham M. West,Bruce D. Pascal,Ned Van Eps,Lydia N. Caro,Sergey A. Vishnivetskiy,Regina J. Lee,Kelly Suino-Powell,Xin Gu,Kuntal Pal,Jinming Ma,Xiaoyong Zhi,Sébastien Boutet,Garth J. Williams,Marc Messerschmidt,Cornelius Gati,Nadia A. Zatsepin,Dingjie Wang,Daniel James,Shibom Basu,Shatabdi Roy-Chowdhury,Chelsie E. Conrad,Jesse Coe,Haiguang Liu,Stella Lisova,Christopher Kupitz,Ingo Grotjohann,Raimund Fromme,Yi Jiang,Minjia Tan,Huaiyu Yang,Jun Li,Meitian Wang,Zhong Zheng,Dianfan Li,Nicole Howe,Yingming Zhao,Jörg Standfuss,Kay Diederichs,Yuhui Dong,Clinton S. Potter,Bridget Carragher,Martin Caffrey,Hualiang Jiang,Henry N. Chapman,John C. H. Spence,Petra Fromme,Uwe Weierstall,Oliver P. Ernst,Vsevolod Katritch,Vsevolod V. Gurevich,Patrick R. Griffin,Wayne L. Hubbell,Raymond C. Stevens,Vadim Cherezov,Karsten Melcher,H. Eric Xu +71 more
TL;DR: The crystal structure of a constitutively active form of human rhodopsin bound to a pre-activated form of the mouse visual arrestin is determined by serial femtosecond X-ray laser crystallography and provides a basis for understanding GPCR-mediated arrestin-biased signalling.
Journal ArticleDOI
Structural Features for Functional Selectivity at Serotonin Receptors
Daniel Wacker,Chong Wang,Vsevolod Katritch,Gye Won Han,Xi Ping Huang,Eyal Vardy,John D. McCorvy,Yi Jiang,Yi Jiang,Meihua Chu,Fai Yiu Siu,Wei Liu,H. Eric Xu,Vadim Cherezov,Bryan L. Roth,Raymond C. Stevens +15 more
TL;DR: Biochemical studies showing that the hallucinogen lysergic acid diethylamide, its precursor ergotamine (ERG), and related ergolines display strong functional selectivity for β-arrestin signaling at the 5-HT2B 5-hydroxytryptamine (5-HT) receptor, whereas they are relatively unbiased at the 4-HT1B receptor are reported.
Journal ArticleDOI
Structural Basis for Molecular Recognition at Serotonin Receptors
Chong Wang,Yi Jiang,Yi Jiang,Jinming Ma,Jinming Ma,Huixian Wu,Daniel Wacker,Vsevolod Katritch,Gye Won Han,Wei Liu,Xi Ping Huang,Eyal Vardy,John D. McCorvy,Xiang Gao,X. Edward Zhou,Karsten Melcher,Chenghai Zhang,Fang Bai,Huaiyu Yang,Linlin Yang,Hualiang Jiang,Bryan L. Roth,Vadim Cherezov,Raymond C. Stevens,H. Eric Xu +24 more
TL;DR: Crystal structures of the human 5-HT1B G protein–coupled receptor bound to the agonist antimigraine medications ergotamine and dihydroergotamine are reported and provide a comprehensive structural basis for understanding receptor-ligand interactions and designing subtype-selective serotonergic drugs.