Y
Yanyong Kang
Researcher at Van Andel Institute
Publications - 21
Citations - 2086
Yanyong Kang is an academic researcher from Van Andel Institute. The author has contributed to research in topics: Rhodopsin & Arrestin. The author has an hindex of 15, co-authored 21 publications receiving 1598 citations. Previous affiliations of Yanyong Kang include Chinese Academy of Sciences & Takeda Pharmaceutical Company.
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Journal ArticleDOI
Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
Yanyong Kang,X. Edward Zhou,Xiang Gao,Yuanzheng He,Wei Liu,Andrii Ishchenko,Anton Barty,Thomas A. White,Oleksandr Yefanov,Gye Won Han,Qingping Xu,Parker W. de Waal,Jiyuan Ke,M. H. Eileen Tan,Chenghai Zhang,Arne Moeller,Graham M. West,Bruce D. Pascal,Ned Van Eps,Lydia N. Caro,Sergey A. Vishnivetskiy,Regina J. Lee,Kelly Suino-Powell,Xin Gu,Kuntal Pal,Jinming Ma,Xiaoyong Zhi,Sébastien Boutet,Garth J. Williams,Marc Messerschmidt,Cornelius Gati,Nadia A. Zatsepin,Dingjie Wang,Daniel James,Shibom Basu,Shatabdi Roy-Chowdhury,Chelsie E. Conrad,Jesse Coe,Haiguang Liu,Stella Lisova,Christopher Kupitz,Ingo Grotjohann,Raimund Fromme,Yi Jiang,Minjia Tan,Huaiyu Yang,Jun Li,Meitian Wang,Zhong Zheng,Dianfan Li,Nicole Howe,Yingming Zhao,Jörg Standfuss,Kay Diederichs,Yuhui Dong,Clinton S. Potter,Bridget Carragher,Martin Caffrey,Hualiang Jiang,Henry N. Chapman,John C. H. Spence,Petra Fromme,Uwe Weierstall,Oliver P. Ernst,Vsevolod Katritch,Vsevolod V. Gurevich,Patrick R. Griffin,Wayne L. Hubbell,Raymond C. Stevens,Vadim Cherezov,Karsten Melcher,H. Eric Xu +71 more
TL;DR: The crystal structure of a constitutively active form of human rhodopsin bound to a pre-activated form of the mouse visual arrestin is determined by serial femtosecond X-ray laser crystallography and provides a basis for understanding GPCR-mediated arrestin-biased signalling.
Journal ArticleDOI
Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors
X. Edward Zhou,X. Edward Zhou,Yuanzheng He,Parker W. de Waal,Xiang Gao,Yanyong Kang,Ned Van Eps,Yanting Yin,Yanting Yin,Kuntal Pal,Devrishi Goswami,Thomas A. White,Anton Barty,Naomi R. Latorraca,Henry N. Chapman,Wayne L. Hubbell,Ron O. Dror,Raymond C. Stevens,Raymond C. Stevens,Vadim Cherezov,Vsevolod V. Gurevich,Patrick R. Griffin,Oliver P. Ernst,Karsten Melcher,H. Eric Xu,H. Eric Xu +25 more
TL;DR: An X-ray free electron laser (XFEL) crystal structure of the rhodopsin-arrestin complex is reported, in which the phosphorylated C terminus of r Rhodopsin forms an extended intermolecular β sheet with the N-terminal β strands of arrestin.
Journal ArticleDOI
Cryo-EM structure of human rhodopsin bound to an inhibitory G protein
Yanyong Kang,Oleg Kuybeda,Parker W. de Waal,Somnath Mukherjee,Ned Van Eps,Przemysław Dutka,Przemysław Dutka,X. Edward Zhou,Alberto Bartesaghi,Satchal K. Erramilli,Takefumi Morizumi,Xin Gu,Yanting Yin,Ping Liu,Yi Jiang,Xing Meng,Gongpu Zhao,Karsten Melcher,Oliver P. Ernst,Anthony A. Kossiakoff,Sriram Subramaniam,H. Eric Xu,H. Eric Xu +22 more
TL;DR: It is shown that the major interactions between activated rhodopsin and Gi are mediated by the C-terminal helix of the Gi α-subunit, which is wedged into the cytoplasmic cavity of the transmembrane helix bundle and directly contacts the amino terminus of helix 8 of rhodopin.
ComponentDOI
Structure and dynamics of the active human parathyroid hormone receptor-1.
Li Zhao,Shanshan Ma,Ieva Sutkeviciute,D.-D. Shen,X.E. Zhou,P.W. de Waal,Chuankui Li,Yanyong Kang,Lisa J. Clark,Frederic Jean-Alphonse,Alex D. White,D. Yang,Antao Dai,Xiaoqing Cai,Jianmin Chen,C. Li,Yi Jiang,Tomoyuki Watanabe,Thomas J. Gardella,Karsten Melcher,Ming-Wei Wang,Ming-Wei Wang,Jean-Pierre Vilardaga,H.E. Xu,H.E. Xu,Yan Zhang +25 more
TL;DR: The cryo–electron microscopy structure of human PTH1R bound to a long-acting PTH analog and the stimulatory G protein is reported, providing insights into the structural basis and dynamics of PTH binding and receptor activation.
Journal ArticleDOI
Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-ligase signaling effector DWARF3.
Lihua Zhao,Lihua Zhao,X. Edward Zhou,Wei Yi,Wu Zhongshan,Wu Zhongshan,Wu Zhongshan,Yue Liu,Yanyong Kang,Li Hou,Li Hou,Parker W. de Waal,Suling Li,Yi Jiang,Adrian Scaffidi,Gavin R. Flematti,Steven M. Smith,Steven M. Smith,Steven M. Smith,Vinh Q. Lam,Patrick R. Griffin,Yonghong Wang,Jiayang Li,Karsten Melcher,Karsten Melcher,H. Eric Xu,H. Eric Xu +26 more
TL;DR: D14 is destabilized upon the binding of ligands and D3, thus revealing an unusual mechanism of SL recognition and signaling, in which the hormone, the receptor, and the downstream effectors are systematically destabilized during the signal transduction process.