P
Pachiappan Arjunan
Researcher at Georgia Regents University
Publications - 27
Citations - 1072
Pachiappan Arjunan is an academic researcher from Georgia Regents University. The author has contributed to research in topics: Angiogenesis & Platelet-derived growth factor. The author has an hindex of 14, co-authored 26 publications receiving 879 citations. Previous affiliations of Pachiappan Arjunan include Sun Yat-sen University & National University of Singapore.
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Journal ArticleDOI
VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis
Fan Zhang,Zhongshu Tang,Xu Hou,Johan Lennartsson,Yang Li,Alexander W. Koch,Pierre Scotney,Chunsik Lee,Pachiappan Arjunan,Lijin Dong,Anil Kumar,Tuomas T. Rissanen,Bin Wang,Nobuo Nagai,Pierre Fons,Robert N. Fariss,Yongqing Zhang,Eric F. Wawrousek,Ginger Tansey,James Raber,Guo-Hua Fong,Hao Ding,David A. Greenberg,Kevin G. Becker,Jean-Marc Herbert,Andrew D. Nash,Seppo Ylä-Herttuala,Yihai Cao,Ryan J. Watts,Xuri Li +29 more
TL;DR: This work indicates that the function of VEGF-B in the vascular system is to act as a “survival,” rather than an “angiogenic” factor and that VEGf-B inhibition may offer new therapeutic opportunities to treat neovascular diseases.
Journal ArticleDOI
DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis
Rajneesh Pathania,Sabarish Ramachandran,Selvakumar Elangovan,Ravi Padia,Pengyi Yang,Senthilkumar Cinghu,Rajalakshmi Veeranan-Karmegam,Pachiappan Arjunan,Jaya P. Gnana-Prakasam,Fulzele Sadanand,Lirong Pei,Chang Sheng Chang,Jeong Hyeon Choi,Huidong Shi,Santhakumar Manicassamy,Puttur D. Prasad,Suash Sharma,Vadivel Ganapathy,Raja Jothi,Muthusamy Thangaraju +19 more
TL;DR: An essential role for DNMT1 is uncovered in MaSC and CSC maintenance and theDNMT1-ISL1 axis is identified as a potential therapeutic target for breast cancer treatment.
Journal ArticleDOI
Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3β phosphorylation
Zhongshu Tang,Pachiappan Arjunan,Chunsik Lee,Yang Li,Anil Kumar,Xu Hou,Bin Wang,Piotr Wardega,Fan Zhang,Lijin Dong,Yongqing Zhang,Shi Zhuang Zhang,Hao Ding,Robert N. Fariss,Kevin G. Becker,Johan Lennartsson,Nobuo Nagai,Yihai Cao,Xuri Li +18 more
TL;DR: The data demonstrate that PDGF-CC is critically required for neuronal survival and may potentially be used to treat neurodegenerative diseases.
Journal ArticleDOI
VEGF-B: a survival, or an angiogenic factor?
Xuri Li,Chunsik Lee,Zhongshu Tang,Fan Zhang,Pachiappan Arjunan,Yang Li,Xu Hou,Anil Kumar,Lijin Dong +8 more
TL;DR: VEGF-B is the first member of the VEGF family that has a potent survival/anti-apoptotic effect, while lacking a general angiogenic activity, and implicates a therapeutic potential of VEGf-B in treating different types of vascular and neurodegenerative diseases.
Journal ArticleDOI
PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets
Xu Hou,Anil Kumar,Chunsik Lee,Bin Wang,Pachiappan Arjunan,Lijin Dong,Arvydas Maminishkis,Zhongshu Tang,Yang Li,Fan Zhang,Shi Zhuang Zhang,Piotr Wardega,Sagarika Chakrabarty,Baoying Liu,Zhijian Wu,Peter Colosi,Robert N. Fariss,Johan Lennartsson,Robert B. Nussenblatt,J. Silvio Gutkind,Yihai Cao,Xuri Li +21 more
TL;DR: PDGF-CC was identified as an important candidate target gene for antiangiogenic therapy, and its inhibition may be of therapeutic value in treating neovascular diseases.