P
Pranesh Kumar
Researcher at Babasaheb Bhimrao Ambedkar University
Publications - 27
Citations - 434
Pranesh Kumar is an academic researcher from Babasaheb Bhimrao Ambedkar University. The author has contributed to research in topics: Western blot & Betulinic acid. The author has an hindex of 9, co-authored 27 publications receiving 275 citations.
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Journal ArticleDOI
Isolated mangiferin and naringenin exert antidiabetic effect via PPARγ/GLUT4 dual agonistic action with strong metabolic regulation.
Ashok K. Singh,Vinit Raj,Amit K Keshari,Amit Rai,Pranesh Kumar,Atul Rawat,Biswanath Maity,Dinesh Kumar,Anand Prakash,Arnab De,Amalesh Samanta,Bolay Bhattacharya,Sudipta Saha +12 more
TL;DR: SA1 and SA2 might be potential antidiabetic lead compounds for future drug development after it was suggested that both compounds reduced blood glucose level, restored body weight, and normalized lipid concentrations in the serum and oxidative stress biomarkers in the liver and pancreas.
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Isolated flavonoids from Ficus racemosa stem bark possess antidiabetic, hypolipidemic and protective effects in albino Wistar rats.
Amit K Keshari,Ghanendra Kumar,Priya Singh Kushwaha,Monika Bhardwaj,Pranesh Kumar,Atul Rawat,Atul Rawat,Dinesh Kumar,Anand Prakash,Balaram Ghosh,Sudipta Saha +10 more
TL;DR: The isolated four flavonoids demonstrated good antidi diabetic, hypolipidemic and antioxidant properties in STZ diabetic rats which supported the use of FR stem bark as useful supplementary drug for future antidiabetic therapy.
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Betulinic acid as apoptosis activator: Molecular mechanisms, mathematical modeling and chemical modifications.
TL;DR: The molecular mechanisms underlying the action of BA and future directions to apply mathematical modeling technique to better understand the precise mechanism of BA‐induced apoptosis are summed up.
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Poly(lactic-co-glycolic acid)-loaded nanoparticles of betulinic acid for improved treatment of hepatic cancer: characterization, in vitro and in vivo evaluations.
Pranesh Kumar,Ashok K. Singh,Vinit Raj,Amit Rai,Amit K Keshari,Dinesh Kumar,Biswanath Maity,Anand Prakash,Sabyasachi Maiti,Sudipta Saha +9 more
TL;DR: The prepared BNP showed a better therapeutic response against HCC and could be attributed as future candidate molecule for HCC treatment.
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Novel 1,3,4-thiadiazoles inhibit colorectal cancer via blockade of IL-6/COX-2 mediated JAK2/STAT3 signals as evidenced through data-based mathematical modeling
Vinit Raj,Archana S. Bhadauria,Ashok K. Singh,Umesh Kumar,Amit Rai,Amit K Keshari,Pranesh Kumar,Dinesh Kumar,Biswanath Maity,Sneha Nath,Anand Prakash,Kausar M. Ansari,Jawahar L. Jat,Sudipta Saha +13 more
TL;DR: The tumor protecting ability of VR24 and VR27 was found comparable or to some degree better than the marketed chemotherapeutics, 5-flurouracil.