Showing papers in "Cytokine in 2019"

TL;DR: The senescence-associated secretory phenotype (SASP) defines the ability of senescent cells to express and secrete a variety of extracellular modulators that includes cytokines, chemokines, proteases, growth factors and bioactive lipids.

TL;DR: Improved understanding of the NK cell response to cytokines has provided a better understanding of their impaired function in tumors which may aid in the development of novel immunotherapeutic strategies to enhance NK cell responses in cancer patients.

TL;DR: The current state of knowledge of the intra- and intermolecular regulation of the JAK-STAT pathway is discussed, with a focus on diseases arising from disruptions in the regulatory apparatus.

TL;DR: This review provides an updated 'state-of-the-art' about the leptin and its role in the pathophysiology of metabolic syndrome at the molecular level.

TL;DR: The aim of this review is to summarize the role of this cytokine in tumorigenesis, angiogenesis and metastasis of CRC and discuss its value in diagnosis, prognosis and treatment of CRC.

TL;DR: Plasma levels of IP‐10 are up‐regulated after HIV infection and positively correlated with HIV disease progression, the positive association between plasma IP-10 levels and HIV disease progress, the effect ofIP‐10 on human immune cells, and potential related mechanisms are summarized.

TL;DR: The current state of knowledge regarding the pro-inflammatory and disease-modulating role of the IL-1 family in atherosclerosis, myocardial infarction, aneurysm, stroke, and other CVDs is summarized.

TL;DR: Due to difficulties in separation of the metabolic effect from the mechanical effect of fat excess, researches on osteoarthritis in non-weight-bearing joints may provide a promising direction and more emphasis shall be put on them in future.

TL;DR: The study pinpoints key role of mTORC2-Akt1 axis in OSM induced macrophage polarization and suggests for possible usage of Oncostatin-M blockade and/or selective m TORC2 inhibition as a potential anti-cancer strategy particularly with reference to metastasis of breast cancer to distant organs such as lung, liver and bone.

TL;DR: The results suggest that quercetin attenuates TNF‐&agr;‐induced ICAM‐1 and MMP‐9 expression in ARPE‐19 cells via the MEK1–ERK1/2 and PKC&dgr;–JNK1–c‐Jun or NF‐&kgr;B pathways.

TL;DR: Two different methods based on Nanostring or RT‐qPCR are proposed to measure in the clinical routine the IFN response, defined as a set of transcripts that are systemically induced by IFNs, which represent a more reliable assay for the daily clinical practice.

TL;DR: This review provides a concise overview of the current knowledge on STAT3 during tumorigenesis, with special emphasis on the unique and complex roles of its alternatively spliced isoforms.

TL;DR: It is highlighted that the adverse effects of excessive exercise go beyond performance decline, proposing a multi-organ approach for this issue and recent insights will allow coaches and exercise physiologists to develop strategies to avoid chronic excessive exercise-induced adverse outcomes.

TL;DR: The present results support previous observations on the protective role of P53 against inflammation and clarify mechanisms that govern vascular barrier function.

TL;DR: The findings suggest that ER stress and the subsequent UPR on the one hand, and the inflammatory response on the other create a kind of feed forward loop, which can be either beneficial (e.g., elimination of the pathogen and restoration of tissue homeostasis) or deleterious (e-g., excessive cell dysfunction and cell death).

TL;DR: G-CSF treatment was associated with a signal of increased risk for aortitis among patients with malignant neoplasms, and three different G- CSF agents were associated with such risk, implying that it is a class effect.

TL;DR: The results revealed the crucial roles of CCL2 and CCL7, but not CCL12, in neuropathic pain development and indicated that pharmacological modulation of these factors may serve as a potential therapeutic target for new (co)analgesics.

TL;DR: The role of immunological abnormalities in the ATD pathogenesis is described and it is shown that for some cells and cytokines their respective roles are not clear, and bi‐directional action is possible.

TL;DR: Systemic and durable changes in the concentrations of inflammatory cytokines and lipid mediators in both PTB and EPTB are described and the role of M. tuberculosis bacterial burden and site of disease in modulating patient immune biomarkers is emphasized.

TL;DR: The data from in vivo experiments showed that pretreatment of mice with UA significantly suppressed xylene-induced ear oedema as well as protected against LPS-induced AKI, suggesting that UA is a potential anti-inflammatory natural compound for treating AKI by inducing autophagy.

TL;DR: This review focuses on the consequences of altered GH - JAK2 - STAT5 signaling for hepatic lipid metabolism and liver cancer development with an emphasis on lessons learned from genetic knockout models.

TL;DR: The results demonstrate that resistin promotes the metastatic potential of breast cancer cells by inducing EMT and stemness and some of these effects are mediated by CAP1.

TL;DR: An involvement of chronic inflammation linked to coronary artery calcification that is likely to contribute to the cardiovascular mortality in patients with impaired renal function is suggested.

TL;DR: The results suggest a possible link between CTRP12 and pathogenic mechanisms of atherosclerosis, such as inflammation and high density lipoprotein‐cholesterol metabolism; however, more study is required in this regard.

TL;DR: Increased levels of chronic inflammatory and oxidative stress markers were observed in both endometrial carcinoma and diabetes, and additional effect of diabetes in patients with cancer was mediated more significantly via increase in oxidative stress rather than inflammatory markers.

TL;DR: The results demonstrate a previously undescribed mechanism by which hyperactivation of the NLRP3 Inflammasome protects mice from IAV infection through IL-1β mediated neutrophil recruitment, and suggest that positively fine tuning the physiological function ofNLRP3 inflammasomes can be beneficial for a mammalian host against IAV challenge.

TL;DR: Findings indicate that overproduction of interferon (IFN)-γ and TNF-α reflected by increased serum levels of neopterin and sTNFR-II are closely associated with the pathogenesis of MAS associated with Kawasaki disease.

TL;DR: The contribution of the IL-17 in mediating fibrotic diseases in various organs is outlined and a comprehensive understanding of the inflammatory events, and particularly the details of IL- 17 signaling in vivo, could be beneficial in designing new therapeutic or preventive approaches to treat fibrosis.

TL;DR: The ability of tea polyphenols to exert an anti‐inflammatory effect and to attenuate the gingival epithelial barrier dysfunction induced by TNF‐&agr; supports their potential for the prevention and treatment of periodontal disease.

TL;DR: It is proposed that the tumour necrosis factor-α converting enzyme ADAM-17 could be the master molecule involved in regulating IL-6 class switching and through this in controlling pro- and anti-inflammatory responses to viral antigenic stimuli.