Mehboob A. Hussain

TL;DR: The results indicate the existence of a bone-pancreas endocrine loop through which insulin signaling in the osteoblasts ensures osteoblast differentiation and stimulates osteocalcin production, which in turn regulates insulin sensitivity and pancreatic insulin secretion.

TL;DR: Both the antidiabetic agent metformin and insulin phosphorylate the transcriptional coactivator CREB binding protein (CBP) at serine 436 via PKC iota/lambda, which triggers the dissociation of the CREB-CBP-TORC2 transcription complex and reduces gluconeogenic enzyme gene expression.

TL;DR: Intraperitoneal administration of GO-CoA-Tat improves glucose tolerance and reduces weight gain in wild-type mice but not in ghrelin-deficient mice, supporting the concept that its beneficial metabolic effects are due specifically to GOAT inhibition.

TL;DR: It is shown that pharmacological metformin concentration increases mitochondrial respiration, membrane potential, and ATP levels in hepatocytes and a clinically relevant met formin dose increases liver mitochondrial density and complex 1 activity along with improved hyperglycemia in high-fat- diet (HFD)-fed mice, suggesting a mechanism for metformIn’s anti-tumor effects.

TL;DR: It is shown that glucagon stimulates via cAMP-PKA-CREB signaling hepatic production of the neuropeptide kisspeptin1, which acts on β cells to suppress GSIS, and this indicates a hormonal circuit between the liver and the endocrine pancreas in glycemia regulation and suggests in T2DM a sequential link between hyperglucagonemia via hepatic kisspe leptin1 to impaired insulin secretion.