Susanna Scafidi

TL;DR: The fine-tuned biochemical specialization of astrocytes allows cells to respond to subtle changes in neurotransmission by dynamically adjusting their anaplerotic and glycolytic activities, and adjusting the amount of glutamate oxidized for energy relative to direct formation of glutamine, to meet the demands for maintaining neurotransmission.

TL;DR: This study provides direct evidence that targeting EGFR in oligodendrocyte progenitor cells at a specific time after injury is clinically feasible and potentially applicable to the treatment of premature children with white matter injury.

TL;DR: The data show that hepatic fatty acid oxidation is not required for survival during acute food deprivation but essential for constraining adipocyte lipolysis and regulating systemic catabolism when glucose is limiting.

TL;DR: Examining fatty acid uptake by bone and disrupting the expression of carnitine palmitoyltransferase 2 in osteoblasts and osteocytes demonstrate a requirement for fatty acid oxidation during bone accrual and suggest a role for the skeleton in lipid homeostasis.

TL;DR: The metabolic changes observed in three major categories of injury that can result in life-long cognitive and neurological disabilities, including neonatal hypoxia–ischemia, pediatric traumatic brain injury, and brain injury secondary to prematurity are reviewed.