Prosenjit Mondal

TL;DR: It is shown that glucagon stimulates via cAMP-PKA-CREB signaling hepatic production of the neuropeptide kisspeptin1, which acts on β cells to suppress GSIS, and this indicates a hormonal circuit between the liver and the endocrine pancreas in glycemia regulation and suggests in T2DM a sequential link between hyperglucagonemia via hepatic kisspe leptin1 to impaired insulin secretion.

TL;DR: The results reveal that TiPARP can mediate a TCDD effect, that the AHR is linked to PGC1α function and stability and that NAM has novel AHR antagonist activity.

TL;DR: It is shown that incretin-stimulated pathways converge at the level of snapin, and that PKA-dependent phosphorylation ofsnapin increases interaction among insulin secretory vesicle-associated proteins, thereby potentiating glucose- Stimulated insulin secretion (GSIS).

TL;DR: Functional analysis of genes associated with differentially DNA-methylated genomic regions revealed four genes with roles in insulin resistance, demonstrating the potential general utility of this approach for complementing conventional human genetic studies by integrating cross-species epigenomics and clinical genetic risk.

TL;DR: Several miRNAs had been discovered from trematodes, nematodes and cestodes with potential role in immune modulation, which might serve as novel targets for therapeutic intervention or biomarkers for parasitic infections.