Glucagon regulates hepatic kisspeptin to impair insulin secretion.
Woo Jin Song,Prosenjit Mondal,Andrew Wolfe,Laura C. Alonso,Rachel E. Stamateris,Benny W.T. Ong,Owen C. Lim,Kil S. Yang,Sally Radovick,Horacio J. Novaira,Emily Farber,Charles R. Farber,Stephen D. Turner,Mehboob A. Hussain +13 more
TLDR
It is shown that glucagon stimulates via cAMP-PKA-CREB signaling hepatic production of the neuropeptide kisspeptin1, which acts on β cells to suppress GSIS, and this indicates a hormonal circuit between the liver and the endocrine pancreas in glycemia regulation and suggests in T2DM a sequential link between hyperglucagonemia via hepatic kisspe leptin1 to impaired insulin secretion.About:
This article is published in Cell Metabolism.The article was published on 2014-04-01 and is currently open access. It has received 172 citations till now. The article focuses on the topics: Glucagon secretion & Hyperglucagonemia.read more
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Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies.
TL;DR: This review collates internationally generated information on metabolic syndrome, its many definitions and its associations with life‐threatening conditions including type 2 diabetes mellitus, cardiovascular disease and cancer, providing a foundation for future advancements on this topic.
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Metabolism disrupting chemicals and metabolic disorders
Jerrold J. Heindel,Bruce Blumberg,Mathew C. Cave,Ronit Machtinger,Alberto Mantovani,Michelle A. Mendez,Angel Nadal,Paola Palanza,Giancarlo Panzica,Robert M. Sargis,Laura N. Vandenberg,Frederick S. vom Saal +11 more
TL;DR: This review will examine changes to the incidence of obesity, T2D and non-alcoholic fatty liver disease (NAFLD), the contribution of genetics to these disorders and describe the role of the endocrine system in these metabolic disorders.
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SGLT2 Inhibitors May Predispose to Ketoacidosis
TL;DR: There are several biologically plausible mechanisms whereby this class of drugs has the potential to increase the risk of developing diabetic ketoacidosis.
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The Role of Placental Hormones in Mediating Maternal Adaptations to Support Pregnancy and Lactation
TL;DR: The changes that occur in maternal physiology in response to pregnancy and the significance of placental hormone production in mediating such changes are examined.
Journal ArticleDOI
The New Biology and Pharmacology of Glucagon.
TL;DR: This review summarizes the extensive historical record and the more recent provocative direction that integrates the prominent role of glucagon in glucose elevation with its under-acknowledged effects on lipids, body weight, and vascular health that have implications for the pathophysiology of metabolic diseases, and the emergence of precision medicines to treat metabolic diseases.
References
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Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor.
Tetsuya Ohtaki,Yasushi Shintani,Susumu Honda,Hirokazu Matsumoto,Akira Hori,Kimiko Kanehashi,Yasuko Terao,Satoshi Kumano,Yoshihiro Takatsu,Yasushi Masuda,Yoshihiro Ishibashi,Takuya Watanabe,Mari Asada,Takao Yamada,Masato Suenaga,Chieko Kitada,Satoshi Usuki,Tsutomu Kurokawa,Haruo Onda,Osamu Nishimura,Masahiko Fujino +20 more
TL;DR: It is shown that KiSS-1 encodes a carboxy-terminally amidated peptide with 54 amino-acid residues, which is isolated from human placenta as the endogenous ligand of an orphan G-protein-coupled receptor (hOT7T175) and named ‘metastin’.
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NCBI GEO: mining millions of expression profiles—database and tools
Tanya Barrett,Tugba O. Suzek,Dennis B. Troup,Stephen E. Wilhite,Wing-Chi Ngau,Pierre Ledoux,Dmitry Rudnev,Alex E. Lash,Wataru Fujibuchi,Ron Edgar +9 more
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Induction of Pancreatic Differentiation by Signals from Blood Vessels
TL;DR: A role for blood vessels as a source of developmental signals during pancreatic organogenesis is demonstrated and results indicate that vessels not only provide metabolic sustenance, but also provide inductive signals for organ development.
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