P
Proszenyák Ágnes
Publications - 22
Citations - 918
Proszenyák Ágnes is an academic researcher. The author has contributed to research in topics: Alkyl & Cell killing. The author has an hindex of 6, co-authored 22 publications receiving 719 citations.
Papers
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Journal ArticleDOI
The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models
András Kotschy,Szlávik Zoltán,James A. H. Murray,James Edward Paul Davidson,Ana Leticia Maragno,Gaëtane Le Toumelin-Braizat,Maïa Chanrion,Gemma L. Kelly,Gemma L. Kelly,Jia-Nan Gong,Jia-Nan Gong,Donia M Moujalled,Alain Bruno,Csékei Márton,Attila Paczal,Zoltán B. Szabó,Szabolcs Sipos,Gabor Radics,Proszenyák Ágnes,Balázs Bálint,Levente Ondi,Gábor Blasko,Alan P. Robertson,Allan E. Surgenor,Pawel Dokurno,Chen I-Jen,Natalia Matassova,Julia Smith,C. Pedder,Chris Graham,Aurélie Studeny,Gaëlle Lysiak-Auvity,Anne-Marie Girard,Fabienne Gravé,David J. Segal,David J. Segal,Chris D. Riffkin,Chris D. Riffkin,Giovanna Pomilio,Laura C. A. Galbraith,Laura C. A. Galbraith,Brandon J. Aubrey,Brandon J. Aubrey,Brandon J. Aubrey,Margs S. Brennan,Margs S. Brennan,Marco J Herold,Marco J Herold,Catherine Chang,Catherine Chang,Ghislaine Guasconi,Nicolas Cauquil,Fabien Melchiore,Nolwen Guigal-Stephan,Brian Lockhart,Frédéric Colland,John A. Hickman,Andrew W. Roberts,David C.S. Huang,David C.S. Huang,Andrew H. Wei,Andrew H. Wei,Andreas Strasser,Andreas Strasser,Guillaume Lessene,Guillaume Lessene,Olivier Geneste +66 more
TL;DR: It is demonstrated that S63845 potently kills MCL1-dependent cancer cells, including multiple myeloma, leukaemia and lymphoma cells, by activating the BAX/BAK-dependent mitochondrial apoptotic pathway.
Journal ArticleDOI
Discovery of S64315, a Potent and Selective Mcl-1 Inhibitor
Szlávik Zoltán,Csékei Márton,Attila Paczal,Zoltán B. Szabó,Szabolcs Sipos,Gabor Radics,Proszenyák Ágnes,Balázs Bálint,James Murray,James Edward Paul Davidson,Chen I-Jen,Pawel Dokurno,Allan E. Surgenor,Zoe Daniels,Roderick E. Hubbard,Gaëtane Le Toumelin-Braizat,Audrey Claperon,Gaëlle Lysiak-Auvity,Anne-Marie Girard,Alain Bruno,Maïa Chanrion,Frédéric Colland,Ana-Leticia Maragno,Didier Demarles,Olivier Geneste,András Kotschy +25 more
TL;DR: The discovery of the clinical candidate S64315 is reported, a selective small molecule inhibitor of Mcl-1, a antiapoptotic member of the Bcl-2 family of proteins, whose upregulation in human cancers is associated with high tumor grade, poor survival, and resistance to chemotherapy.
Patent
New thienopyrimidine derivatives, a process for their preparation and pharmaceutical compositions containing them
András Kotschy,Szlávik Zoltán,Csékei Márton,Attila Paczal,Szabó Zoltán,Sipos Szabolcs,Gabor Radics,Proszenyák Ágnes,Bálint Balázs,Bruno Alain,Geneste Olivier,James Edward Paul Davidson,James Brooke Murray,Chen I-Jen,Perron-Sierra Françoise +14 more
TL;DR: In this paper, the same authors defined compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R12, X, A and n are as defined in the description.
Patent
New hydroxyacid derivatives, a process for their preparation and pharmaceutical compositions containing them
Szlávik Zoltán,Attila Paczal,Bálint Balázs,András Kotschy,Chanrion Maia,Geneste Olivier,James Edward Paul Davidson,James Brooke Murray,Sipos Szabolcs,Proszenyák Ágnes +9 more
TL;DR: In this article, the authors define a set of compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R14, A and n are as defined in the description.
Patent
Aminoacid derivatives, a process for their preparation and pharmaceutical compositions containing them
Szlávik Zoltán,Szabó Zoltán,Csékei Márton,Attila Paczal,András Kotschy,Bruno Alain,Geneste Olivier,Chen I-Jen,Davidson James Edward Paul,Murray James Brooke,Ondi Levente,Gabor Radics,Sipos Szabolcs,Proszenyák Ágnes,Perron-Sierra Françoise,Bálint Balázs +15 more
TL;DR: In this article, the same authors describe a set of products containing the same which are useful in treating a condition requiring a pro-apoptotic agent, and describe how they can be used in medical applications.