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Szlávik Zoltán
Researcher at Eötvös Loránd University
Publications - 40
Citations - 1071
Szlávik Zoltán is an academic researcher from Eötvös Loránd University. The author has contributed to research in topics: Isoquinoline & Isoindoline. The author has an hindex of 11, co-authored 40 publications receiving 862 citations.
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Journal ArticleDOI
The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models
András Kotschy,Szlávik Zoltán,James A. H. Murray,James Edward Paul Davidson,Ana Leticia Maragno,Gaëtane Le Toumelin-Braizat,Maïa Chanrion,Gemma L. Kelly,Gemma L. Kelly,Jia-Nan Gong,Jia-Nan Gong,Donia M Moujalled,Alain Bruno,Csékei Márton,Attila Paczal,Zoltán B. Szabó,Szabolcs Sipos,Gabor Radics,Proszenyák Ágnes,Balázs Bálint,Levente Ondi,Gábor Blasko,Alan P. Robertson,Allan E. Surgenor,Pawel Dokurno,Chen I-Jen,Natalia Matassova,Julia Smith,C. Pedder,Chris Graham,Aurélie Studeny,Gaëlle Lysiak-Auvity,Anne-Marie Girard,Fabienne Gravé,David J. Segal,David J. Segal,Chris D. Riffkin,Chris D. Riffkin,Giovanna Pomilio,Laura C. A. Galbraith,Laura C. A. Galbraith,Brandon J. Aubrey,Brandon J. Aubrey,Brandon J. Aubrey,Margs S. Brennan,Margs S. Brennan,Marco J Herold,Marco J Herold,Catherine Chang,Catherine Chang,Ghislaine Guasconi,Nicolas Cauquil,Fabien Melchiore,Nolwen Guigal-Stephan,Brian Lockhart,Frédéric Colland,John A. Hickman,Andrew W. Roberts,David C.S. Huang,David C.S. Huang,Andrew H. Wei,Andrew H. Wei,Andreas Strasser,Andreas Strasser,Guillaume Lessene,Guillaume Lessene,Olivier Geneste +66 more
TL;DR: It is demonstrated that S63845 potently kills MCL1-dependent cancer cells, including multiple myeloma, leukaemia and lymphoma cells, by activating the BAX/BAK-dependent mitochondrial apoptotic pathway.
Journal ArticleDOI
Structure-Guided Discovery of a Selective Mcl-1 Inhibitor with Cellular Activity
Szlávik Zoltán,Levente Ondi,Csékei Márton,Attila Paczal,Zoltán B. Szabó,Gabor Radics,James Murray,James Edward Paul Davidson,Chen I-Jen,Ben Davis,Roderick E. Hubbard,C. Pedder,Pawel Dokurno,Allan E. Surgenor,Julia Smith,Alan P. Robertson,Gaetane LeToumelin-Braizat,Nicolas Cauquil,Marion Zarka,Didier Demarles,Perron-Sierra Françoise,Audrey Claperon,Frédéric Colland,Olivier Geneste,András Kotschy +24 more
TL;DR: The discovery of selective small molecule inhibitors of Mcl-1 that inhibit cellular activity is reported, and the obtained compounds described here exhibit nanomolar binding affinity and mechanism-based cellular efficacy, caspase induction, and growth inhibition.
Journal ArticleDOI
Discovery of S64315, a Potent and Selective Mcl-1 Inhibitor
Szlávik Zoltán,Csékei Márton,Attila Paczal,Zoltán B. Szabó,Szabolcs Sipos,Gabor Radics,Proszenyák Ágnes,Balázs Bálint,James Murray,James Edward Paul Davidson,Chen I-Jen,Pawel Dokurno,Allan E. Surgenor,Zoe Daniels,Roderick E. Hubbard,Gaëtane Le Toumelin-Braizat,Audrey Claperon,Gaëlle Lysiak-Auvity,Anne-Marie Girard,Alain Bruno,Maïa Chanrion,Frédéric Colland,Ana-Leticia Maragno,Didier Demarles,Olivier Geneste,András Kotschy +25 more
TL;DR: The discovery of the clinical candidate S64315 is reported, a selective small molecule inhibitor of Mcl-1, a antiapoptotic member of the Bcl-2 family of proteins, whose upregulation in human cancers is associated with high tumor grade, poor survival, and resistance to chemotherapy.
Patent
New thienopyrimidine derivatives, a process for their preparation and pharmaceutical compositions containing them
András Kotschy,Szlávik Zoltán,Csékei Márton,Attila Paczal,Szabó Zoltán,Sipos Szabolcs,Gabor Radics,Proszenyák Ágnes,Bálint Balázs,Bruno Alain,Geneste Olivier,James Edward Paul Davidson,James Brooke Murray,Chen I-Jen,Perron-Sierra Françoise +14 more
TL;DR: In this paper, the same authors defined compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R12, X, A and n are as defined in the description.
Journal ArticleDOI
Convenient syntheses and characterization of fluorophilic perfluorooctyl-propyl amines and ab initio calculations of proton affinities of related model compounds
TL;DR: In this article, a method for the preparation of perfluorooctyl-propyl amines via a step-by-step alkylation with R f8 (CH 2 ) 3 I is described.