C
Chris Graham
Researcher at University of Manitoba
Publications - 18
Citations - 2056
Chris Graham is an academic researcher from University of Manitoba. The author has contributed to research in topics: DNA damage & Membrane protein. The author has an hindex of 11, co-authored 18 publications receiving 1734 citations. Previous affiliations of Chris Graham include HealthPartners & University of Regina.
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Journal ArticleDOI
The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models
András Kotschy,Szlávik Zoltán,James A. H. Murray,James Edward Paul Davidson,Ana Leticia Maragno,Gaëtane Le Toumelin-Braizat,Maïa Chanrion,Gemma L. Kelly,Gemma L. Kelly,Jia-Nan Gong,Jia-Nan Gong,Donia M Moujalled,Alain Bruno,Csékei Márton,Attila Paczal,Zoltán B. Szabó,Szabolcs Sipos,Gabor Radics,Proszenyák Ágnes,Balázs Bálint,Levente Ondi,Gábor Blasko,Alan P. Robertson,Allan E. Surgenor,Pawel Dokurno,Chen I-Jen,Natalia Matassova,Julia Smith,C. Pedder,Chris Graham,Aurélie Studeny,Gaëlle Lysiak-Auvity,Anne-Marie Girard,Fabienne Gravé,David J. Segal,David J. Segal,Chris D. Riffkin,Chris D. Riffkin,Giovanna Pomilio,Laura C. A. Galbraith,Laura C. A. Galbraith,Brandon J. Aubrey,Brandon J. Aubrey,Brandon J. Aubrey,Margs S. Brennan,Margs S. Brennan,Marco J Herold,Marco J Herold,Catherine Chang,Catherine Chang,Ghislaine Guasconi,Nicolas Cauquil,Fabien Melchiore,Nolwen Guigal-Stephan,Brian Lockhart,Frédéric Colland,John A. Hickman,Andrew W. Roberts,David C.S. Huang,David C.S. Huang,Andrew H. Wei,Andrew H. Wei,Andreas Strasser,Andreas Strasser,Guillaume Lessene,Guillaume Lessene,Olivier Geneste +66 more
TL;DR: It is demonstrated that S63845 potently kills MCL1-dependent cancer cells, including multiple myeloma, leukaemia and lymphoma cells, by activating the BAX/BAK-dependent mitochondrial apoptotic pathway.
Journal ArticleDOI
ER exit sites are physical and functional core autophagosome biogenesis components
TL;DR: ERES function is required for assembly of the autophagy machinery immediately downstream of the Atg1 kinase complex and is associated with formation of autophagosomes at every stage of the process.
Journal ArticleDOI
A dual function of the CRISPR-Cas system in bacterial antivirus immunity and DNA repair
Mohan Babu,Natalia Beloglazova,Robert Flick,Chris Graham,Tatiana Skarina,Boguslaw Nocek,Alla Gagarinova,Oxana Pogoutse,Greg Brown,Andrew Binkowski,Sadhna Phanse,Andrzej Joachimiak,Eugene V. Koonin,Alexei Savchenko,Andrew Emili,Jack Greenblatt,Aled M. Edwards,Alexander F. Yakunin +17 more
TL;DR: The results show that YgbT belongs to a novel, structurally distinct family of nucleases acting on branched DNAs and suggest that, in addition to antiviral immunity, at least some components of the CRISPR–Cas system have a function in DNA repair.
Journal ArticleDOI
Interaction landscape of membrane - protein complexes in Saccharomyces cerevisiae
Mohan Babu,James Vlasblom,Shuye Pu,Xinghua Guo,Chris Graham,Björn D. M. Bean,Helen E. Burston,Franco J. Vizeacoumar,Jamie Snider,Sadhna Phanse,Vincent Fong,Yuen Yi C. Tam,Michael Davey,Olha Hnatshak,Navgeet Bajaj,Shamanta Chandran,Thanuja Punna,Constantine Christopolous,Victoria Wong,Analyn Yu,Gouqing Zhong,Joyce Li,Igor Stagljar,Elizabeth Conibear,Shoshana J. Wodak,Andrew Emili,Jack Greenblatt +26 more
TL;DR: A complete survey of putative integral, peripheral and lipid-anchored MPs from Saccharomyces cerevisiae was reported, which revealed unexpected physical associations underlying the membrane biology of eukaryotes and delineates the global topological landscape of the membrane interactome.
Journal ArticleDOI
Quantitative Genome-Wide Genetic Interaction Screens Reveal Global Epistatic Relationships of Protein Complexes in Escherichia coli
Mohan Babu,Roland Arnold,Cedoljub Bundalovic-Torma,Alla Gagarinova,Keith S. Wong,Ashwani Kumar,Geordie Stewart,Bahram Samanfar,Hiroyuki Aoki,Omar Wagih,James Vlasblom,Sadhna Phanse,Krunal Lad,Angela Yeou Hsiung Yu,Chris Graham,Ke Jin,Eric D. Brown,Ashkan Golshani,Philip M. Kim,Gabriel Moreno-Hagelsieb,Jack Greenblatt,Walid A. Houry,John Parkinson,Andrew Emili +23 more
TL;DR: Examining bacterial GIs in the context of protein complexes provides avenues for a deeper mechanistic understanding of core microbial systems, including new components required for the biogenesis of iron-sulphur and ribosome integrity, and the interplay between molecular chaperones and proteases.