Deposits of clastic carbonate-dominated (calciclastic) sedimentary slope systems in the rock record have been identified mostly as linearly-consistent carbonate apron deposits, even though most ancient clastic carbonate slope deposits fit the submarine fan systems better. Calciclastic submarine fans are consequently rarely described and are poorly understood. Subsequently, very little is known especially in mud-dominated calciclastic submarine fan systems. Presented in this study are a sedimentological core and petrographic characterisation of samples from eleven boreholes from the Lower Carboniferous of Bowland Basin (Northwest England) that reveals a >250 m thick calciturbidite complex deposited in a calciclastic submarine fan setting. Seven facies are recognised from core and thin section characterisation and are grouped into three carbonate turbidite sequences. They include: 1) Calciturbidites, comprising mostly of highto low-density, wavy-laminated bioclast-rich facies; 2) low-density densite mudstones which are characterised by planar laminated and unlaminated muddominated facies; and 3) Calcidebrites which are muddy or hyper-concentrated debrisflow deposits occurring as poorly-sorted, chaotic, mud-supported floatstones. These

Phd by thesis

I have developed "tennis elbow" from lugging this book around the past four weeks, but it is worth the pain, the effort, and the aspirin. It is also worth the (relatively speaking) bargain price. Including appendixes, this book contains 894 pages of text. The entire panorama of the neural sciences is surveyed and examined, and it is comprehensive in its scope, from genomes to social behaviors. The editors explicitly state that the book is designed as "an introductory text for students of biology, behavior, and medicine," but it is hard to imagine any audience, interested in any fragment of neuroscience at any level of sophistication, that would not enjoy this book. The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or

Principles of Neural Science

BIOE 402. Medical Technology Assessment. 2 or 3 hours. Bioentrepreneur course. Assessment of medical technology in the context of commercialization. Objectives, competition, market share, funding, pricing, manufacturing, growth, and intellectual property; many issues unique to biomedical products. Course Information: 2 undergraduate hours. 3 graduate hours. Prerequisite(s): Junior standing or above and consent of the instructor.

“Bioinformatics” 특집을 내면서

Department of Materials Science, University of Patras, 26504 Rio Patras, Greece, Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, 48 Vass. Constantinou Avenue, 116 35 Athens, Greece, Institut de Biologie Moleculaire et Cellulaire, UPR9021 CNRS, Immunologie et Chimie Therapeutiques, 67084 Strasbourg, France, and Dipartimento di Scienze Farmaceutiche, Universita di Trieste, Piazzale Europa 1, 34127 Trieste, Italy

Chemistry of Carbon Nanotubes

Engineered nanoparticles have the potential to revolutionize the diagnosis and treatment of many diseases; for example, by allowing the targeted delivery of a drug to particular subsets of cells. However, so far, such nanoparticles have not proved capable of surmounting all of the biological barriers required to achieve this goal. Nevertheless, advances in nanoparticle engineering, as well as advances in understanding the importance of nanoparticle characteristics such as size, shape and surface properties for biological interactions, are creating new opportunities for the development of nanoparticles for therapeutic applications. This Review focuses on recent progress important for the rational design of such nanoparticles and discusses the challenges to realizing the potential of nanoparticles.

Strategies in the design of nanoparticles for therapeutic applications

Quantum-Dot-Tagged Microbeads and their Use as Fluorescent Biological Probes

Using multiple nonlinear techniques, we revealed the existence of chaos in the spontaneous activity of neuronal networks in vitro. The spatial-temporal dynamics of these networks indicated that emergent transition between chaotic behavior and superburst occurred periodically in low-frequency oscillations. An analysis of network-wide activity indicated that chaos was synchronized among different sites. Moreover, we found that the degree of chaos increased as the number of active sites in the network increased during long-term development (over three months in vitro). The chaotic behavior of the dissociated networks had similar spatial-temporal characteristics (rapid transition, periodicity, and synchronization) as the intact brain; however, the degree of chaos depended on the number of active sites at the mesoscopic level. This work could provide insight into neural coding and neurocybernetics.

Spatial-temporal dynamics of chaotic behavior in cultured hippocampal networks.

Using the algebra transformation method, we develop and demonstrate the use of the delta-P(1) approximation to improve steady-state radiative-transfer estimates on spatial scales comparable to the mean free path. We show that the delta-P(1) approximation agrees well with Monte Carlo simulation from source to infinity when we choose an appropriate parameter f (fractional portion that scatters directly forward) in the delta-Eddington phase function. We also provide the empirical formula to determine the parameter f.

Improved steady-state diffusion approximation with an anisotropic point source and the δ--Eddington phase function

A novel method of designing a wideband high-isolated dual-antenna pair using dual characteristic modes (CMs) is presented for fifth-generation (5G) multiple-input multiple-output (MIMO) smartphone applications. A set of orthogonal CMs resonating from the square-loop slot is first introduced and works for the lower band. Then, another set of orthogonal CMs resonating from the edge branches is introduced with a shared compact radiator and works for the higher band. In combination with two sets of degenerated CMs and a capacitive coupling feeding structure, the proposed dual-antenna pair achieves a broad impedance bandwidth and high isolation without the need for any external decoupling structures. Based on this dual-antenna pair, an 8×8 MIMO array is developed and integrated into the back cover of a smartphone, which realizes zero ground clearance on the system circuit board. To verify the design concept, prototypes of the antenna pair and MIMO array were fabricated and measured. It shows that experimental results agree well with the simulation results. More importantly, the presented 8×8 MIMO array has high isolation of more than 20 dB is achieved across the operating band of 3.3-3.8 GHz.

Wideband Back-Cover Antenna Design Using Dual Characteristic Modes With High Isolation for 5G MIMO Smartphone

The dorsal raphe nucleus (DR) and median raphe nucleus (MR) contain populations of glutamatergic and GABAergic neurons regulating diverse behavioral functions. Their whole-brain input-output circuits remain incompletely understood. We used viral tracing combined with fluorescence micro-optical sectioning tomography to generate a comprehensive whole-brain atlas of inputs and outputs of glutamatergic and GABAergic neurons in the DR and MR. We discovered that these neurons receive inputs from similar upstream brain regions. The glutamatergic and GABAergic neurons in the same raphe nucleus have divergent projection patterns with differences in critical brain regions. Specifically, MR glutamatergic neurons project to the lateral habenula via multiple pathways. Correlation and cluster analysis indicated that glutamatergic and GABAergic neurons in the same raphe nucleus receive inputs from heterogeneous neurons in upstream brain regions and send different collateral projections. This connectivity atlas provides insights into the cell heterogeneity, anatomical connectivity and behavioral functions of the raphe nucleus.

/pdf/whole-brain-connectivity-atlas-of-glutamatergic-and-1d7ih1trwg.pdf

Qingming Luo

Papers

Quantum-Dot-Tagged Microbeads and their Use as Fluorescent Biological Probes

Spatial-temporal dynamics of chaotic behavior in cultured hippocampal networks.

Improved steady-state diffusion approximation with an anisotropic point source and the δ--Eddington phase function

Wideband Back-Cover Antenna Design Using Dual Characteristic Modes With High Isolation for 5G MIMO Smartphone

Whole-brain connectivity atlas of glutamatergic and GABAergic neurons in mouse dorsal and median raphe nucleus