R
Rachael Instrell
Researcher at Francis Crick Institute
Publications - 13
Citations - 540
Rachael Instrell is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: Ectodomain & Endosome. The author has an hindex of 8, co-authored 13 publications receiving 415 citations. Previous affiliations of Rachael Instrell include London Research Institute.
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Journal ArticleDOI
Multiomic Analysis of the UV-Induced DNA Damage Response.
Stefan Boeing,Laura Williamson,Vesela Encheva,Ilaria Gori,Rebecca E. Saunders,Rachael Instrell,Ozan Aygün,Marta Rodríguez-Martínez,Juston C. Weems,Gavin Kelly,Joan W. Conaway,Joan W. Conaway,Ronald C. Conaway,Ronald C. Conaway,Aengus Stewart,Michael Howell,Ambrosius P. Snijders,Jesper Q. Svejstrup +17 more
TL;DR: A role for the poorly studied, melanoma-associated serine/threonine kinase 19 (STK19) is uncovered, which provides a systems-wide overview of the diverse cellular processes connected to the transcription-related DNA damage response.
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Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila
Michael C. Wehr,Maxine V. Holder,Ieva Gailite,Rebecca E. Saunders,Tobias M. Maile,Elena Ciirdaeva,Rachael Instrell,Ming Jiang,Michael Howell,Moritz J. Rossner,Nicolas Tapon +10 more
TL;DR: The Drosophila salt-inducible kinases (Sik2 and Sik3) are characterized as negative regulators of Hpo signalling and a split-TEV-based genome-wide RNAi screen for modulators of HPO signalling suggests a link between the Hpo pathway and systemic growth control.
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APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability.
Laurent Sansregret,James O. Patterson,Sally M. Dewhurst,Carlos López-García,Andre Koch,Nicholas McGranahan,William C. H. Chao,David J. Barry,Andrew Rowan,Rachael Instrell,Stuart Horswell,Michael Way,Michael Howell,Martin R. Singleton,René H. Medema,Paul Nurse,Mark Petronczki,Mark Petronczki,Charles Swanton +18 more
TL;DR: A mechanism whereby cancers balance the evolutionary advantages associated with CIN against the fitness costs caused by excessive genome instability is reported, providing insight into the consequence of CDC27 APC/C subunit driver mutations in cancer.
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PKCα and PKCδ regulate ADAM17-mediated ectodomain shedding of heparin binding-EGF through separate pathways.
Marie Kveiborg,Marie Kveiborg,Rachael Instrell,Christina Rowlands,Michael Howell,Peter J. Parker,Peter J. Parker +6 more
TL;DR: A cell-based system of PMA-induced PKC activation coupled with shedding of heparin binding (HB)-EGF indicates the existence of multiple modes of regulation controlling EGFR-ligand availability and subsequent EGFR signal transduction.
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A CRISPR platform for targeted in vivo screens identifies Toxoplasma gondii virulence factors in mice
Joanna Young,Caia Dominicus,Jeanette Wagener,Simon Butterworth,Xingda Ye,Gavin Kelly,Merav Ordan,Becky Saunders,Rachael Instrell,Michael Howell,Aengus Stewart,Moritz Treeck +11 more
TL;DR: A method for generating and analysing small scale custom CRISPR libraries is developed and used in the human and livestock pathogen Toxoplasma gondii to identify virulence factors in mice and reveals a potential trans-rescue of individual knock-out parasites in pools of mutants.