R
Rachana Haliyur
Researcher at Vanderbilt University
Publications - 19
Citations - 1200
Rachana Haliyur is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Islet & Type 1 diabetes. The author has an hindex of 12, co-authored 17 publications receiving 916 citations. Previous affiliations of Rachana Haliyur include Vanderbilt University Medical Center & University of Maryland, Baltimore.
Papers
More filters
Journal ArticleDOI
Microglia Are Essential to Masculinization of Brain and Behavior
TL;DR: It is demonstrated that immune cells in the brain interact with the nervous and endocrine systems during development, and are crucial for sexual differentiation of brain and behavior, and the mechanisms underlying this feedforward process were unknown.
Journal ArticleDOI
Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes
Jenny Aurielle B. Babon,Megan E DeNicola,David M. Blodgett,Inne Crèvecoeur,Thomas S Buttrick,René Maehr,Rita Bottino,Ali Naji,John S. Kaddis,Wassim Elyaman,Eddie A. James,Rachana Haliyur,Marcela Brissova,Lut Overbergh,Chantal Mathieu,Thomas Delong,Kathryn Haskins,Alberto Pugliese,Martha Campbell-Thompson,Clayton E. Mathews,Mark A. Atkinson,Alvin C. Powers,Alvin C. Powers,Alvin C. Powers,David M. Harlan,Sally C. Kent +25 more
TL;DR: In this paper, the authors present an analysis of 50 of a total of 236 CD4+ and CD8+ T cell lines grown from individual handpicked islets or clones directly sorted from handpicked, dispersed islets from nine donors with Type 1 diabetes.
Journal ArticleDOI
α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes
Marcela Brissova,Rachana Haliyur,Diane C. Saunders,Shristi Shrestha,Chunhua Dai,David M. Blodgett,David M. Blodgett,Rita Bottino,Martha Campbell-Thompson,Radhika Aramandla,Gregory Poffenberger,Jill Lindner,Fong Cheng Pan,Matthias von Herrath,Dale L. Greiner,Leonard D. Shultz,May Sanyoura,Louis H. Philipson,Mark A. Atkinson,David M. Harlan,Shawn Levy,Nripesh Prasad,Roland Stein,Roland Stein,Alvin C. Powers,Alvin C. Powers,Alvin C. Powers +26 more
TL;DR: It is shown that remnant β cells appeared to maintain several aspects of regulated insulin secretion, however, the function of T1D α cells was markedly reduced, and these cells had alterations in transcription factors constituting α and β cell identity.
Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes (vol 22, pg 1482, 2016)
Jenny Aurielle B. Babon,Megan E DeNicola,David M. Blodgett,Inne Crèvecoeur,Thomas S Buttrick,René Maehr,Rita Bottino,Ali Naji,John S. Kaddis,Wassim Elyaman,Eddie A. James,Rachana Haliyur,Marcela Brissova,Lut Overbergh,Chantal Mathieu,Thomas Delong,Kathryn Haskins,Alberto Pugliese,Martha Campbell-Thompson,Clayton E. Mathews,Mark A. Atkinson,Alvin C. Powers,David M. Harlan,Sally C. Kent +23 more
TL;DR: These studies demonstrate the existence of a variety of is let-infiltrating, islet-autoantigen reactive T cells in individuals with T1D, and these data have implications for the design of successful immunotherapies.
Journal ArticleDOI
HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of islet β-Cells from Donors with Type 1 Diabetes
Mark Russell,Sambra D. Redick,David M. Blodgett,David M. Blodgett,Sarah J. Richardson,Pia Leete,Lars Krogvold,Knut Dahl-Jørgensen,Rita Bottino,Marcela Brissova,Jason M. Spaeth,Jenny Aurielle B. Babon,Rachana Haliyur,Alvin C. Powers,Alvin C. Powers,Alvin C. Powers,Chaoxing Yang,Sally C. Kent,Alan G. Derr,Alper Kucukural,Manuel Garber,Noel G. Morgan,David M. Harlan +22 more
TL;DR: The data demonstrate that pancreatic β-cells from donors with type 1 diabetes express Class II molecules on selected cells with other key genes in those pathways and inflammation-associated genes, suggesting thatβ-cells may interact directly with islet-infiltrating CD4+ T cells and may play an immunopathogenic role.