J
John S. Kaddis
Researcher at City of Hope National Medical Center
Publications - 34
Citations - 2057
John S. Kaddis is an academic researcher from City of Hope National Medical Center. The author has contributed to research in topics: Diabetes mellitus & Type 1 diabetes. The author has an hindex of 16, co-authored 29 publications receiving 1659 citations. Previous affiliations of John S. Kaddis include Beckman Research Institute.
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Journal ArticleDOI
Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes.
Martha Campbell-Thompson,Ann Fu,John S. Kaddis,Clive Wasserfall,Desmond A. Schatz,Alberto Pugliese,Mark A. Atkinson +6 more
TL;DR: The presence of β-cells as well as insulitis several years after diagnosis in children and young adults suggests that the chronicity of islet autoimmunity extends well into the postdiagnosis period.
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Intestinal enteroendocrine lineage cells possess homeostatic and injury-inducible stem cell activity
Kelley S. Yan,Kelley S. Yan,Olivier Gevaert,Grace X.Y. Zheng,Benedict Anchang,Chris Probert,Kathryn A. Larkin,Paige S. Davies,Zhuan fen Cheng,John S. Kaddis,Arnold Han,Arnold Han,Kelly Roelf,Ruben I. Calderon,Esther Cynn,Xiaoyi Hu,Komal Mandleywala,Julie Wilhelmy,Susan M. Grimes,David C Corney,Stéphane C. Boutet,Jessica M. Terry,Phillip Belgrader,Solongo B. Ziraldo,Tarjei S. Mikkelsen,Fengchao Wang,Richard J. von Furstenberg,Nicholas R. Smith,Parthasarathy Chandrakesan,Randal May,Mary Ann S. Chrissy,Rajan Jain,Christine A. Cartwright,Joyce C. Niland,Young-Kwon Hong,Jill L. Carrington,David T. Breault,Jonathan I. Epstein,Courtney W. Houchen,John P. Lynch,Martin G. Martin,Sylvia K. Plevritis,Christina Curtis,Hanlee P. Ji,Linheng Li,Susan J. Henning,Melissa H. Wong,Calvin J. Kuo +47 more
TL;DR: The data suggest that the EE lineage, including mature EE cells, comprises a reservoir of homeostatic and injury-inducible ISCs, extending the understanding of cellular plasticity and stemness.
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Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes
Jenny Aurielle B. Babon,Megan E DeNicola,David M. Blodgett,Inne Crèvecoeur,Thomas S Buttrick,René Maehr,Rita Bottino,Ali Naji,John S. Kaddis,Wassim Elyaman,Eddie A. James,Rachana Haliyur,Marcela Brissova,Lut Overbergh,Chantal Mathieu,Thomas Delong,Kathryn Haskins,Alberto Pugliese,Martha Campbell-Thompson,Clayton E. Mathews,Mark A. Atkinson,Alvin C. Powers,Alvin C. Powers,Alvin C. Powers,David M. Harlan,Sally C. Kent +25 more
TL;DR: In this paper, the authors present an analysis of 50 of a total of 236 CD4+ and CD8+ T cell lines grown from individual handpicked islets or clones directly sorted from handpicked, dispersed islets from nine donors with Type 1 diabetes.
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Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes
Sarah J. Richardson,Teresa Rodriguez-Calvo,Ivan C. Gerling,Clayton E. Mathews,John S. Kaddis,Mark Russell,Marie Zeissler,Pia Leete,Lars Krogvold,Knut Dahl-Jørgensen,Matthias von Herrath,Alberto Pugliese,Mark A. Atkinson,Noel G. Morgan +13 more
TL;DR: Islet cell HLA class I hyperexpression is not an artefact, but is a hallmark in the immunopathogenesis of type 1 diabetes, thereby contributing to their selective susceptibility to autoimmune-mediated destruction.
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Network for Pancreatic Organ Donors with Diabetes (nPOD): developing a tissue biobank for type 1 diabetes.
Martha Campbell-Thompson,Clive Wasserfall,John S. Kaddis,Anastasia Albanese-O'Neill,Teodora Staeva,Concepcion Nierras,Jayne M Moraski,Patrick Rowe,Roberto Gianani,George S. Eisenbarth,James M. Crawford,Desmond A. Schatz,Alberto Pugliese,Mark A. Atkinson +13 more
TL;DR: The Network for Pancreatic Organ Donors with Diabetes was established to recover and characterize pancreata and related organs from cadaveric organ donors with various risk levels for type 1 diabetes.