R
Rachit Badolia
Researcher at University of Utah
Publications - 5
Citations - 183
Rachit Badolia is an academic researcher from University of Utah. The author has contributed to research in topics: Heart failure & Pyruvate decarboxylation. The author has an hindex of 2, co-authored 5 publications receiving 39 citations. Previous affiliations of Rachit Badolia include Intermountain Medical Center.
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Journal ArticleDOI
The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure.
Ahmad A. Cluntun,Rachit Badolia,Sandra Lettlova,K. Mark Parnell,Thirupura S. Shankar,Nikolaos A. Diakos,Kristofor A. Olson,Iosif Taleb,Sean M. Tatum,Jordan A. Berg,Corey N. Cunningham,Tyler Van Ry,Alex J. Bott,Aspasia Thodou Krokidi,Sarah Fogarty,Sophia Skedros,Wojciech I. Swiatek,Xuejing Yu,Bai Luo,Shannon Merx,Sutip Navankasattusas,James E. Cox,Gregory S. Ducker,William L. Holland,Stephen H. McKellar,Stephen H. McKellar,Jared Rutter,Stavros G. Drakos,Stavros G. Drakos +28 more
TL;DR: It is found that alteration of the pyruvate-lactate axis is a fundamental and early feature of cardiac hypertrophy and failure.
Journal ArticleDOI
The Role of Nonglycolytic Glucose Metabolism in Myocardial Recovery Upon Mechanical Unloading and Circulatory Support in Chronic Heart Failure.
Rachit Badolia,Rachit Badolia,Dinesh K. A. Ramadurai,E. Dale Abel,Peter Ferrin,Iosif Taleb,Iosif Taleb,Thirupura S. Shankar,Aspasia Thodou Krokidi,Sutip Navankasattusas,Stephen H. McKellar,Michael Yin,Abdallah G. Kfoury,Omar Wever-Pinzon,James C. Fang,Craig H. Selzman,Craig H. Selzman,Dipayan Chaudhuri,Jared Rutter,Stavros G. Drakos,Stavros G. Drakos +20 more
TL;DR: The recovering heart appears to direct glycolytic metabolites into pentose-phosphate pathway and 1-carbon metabolism, which could contribute to cardioprotection by generating reduced nicotinamide adenine dinucleotide phosphate to enhance biosynthesis and by reducing oxidative stress.
Journal ArticleDOI
Cardiomyocyte Krüppel-Like Factor 5 Promotes De Novo Ceramide Biosynthesis and Contributes to Eccentric Remodeling in Ischemic Cardiomyopathy.
Matthew Hoffman,Dimitra Palioura,Ioannis D. Kyriazis,Maria Cimini,Rachit Badolia,Sudarsan Rajan,Erhe Gao,Nikolas Nikolaidis,P. Christian Schulze,Ira J. Goldberg,Raj Kishore,Vincent W. Yang,Thomas D. Bannister,Agnieszka B. Bialkowska,Craig H. Selzman,Stavros G. Drakos,Konstantinos Drosatos +16 more
TL;DR: In this paper, it was shown that cardiomyocyte Krϋppel-like factor (KLF) 5 regulates cardiac fatty acid oxidation, as heart failure has been associated with altered fatty acid acid oxidation.
Journal ArticleDOI
Cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis.
Thirupura S. Shankar,Dinesh K. A. Ramadurai,Kira Steinhorst,Salah Sommakia,Rachit Badolia,Aspasia Thodou Krokidi,Dallen Calder,Sutip Navankasattusas,Paulina Sander,Oh Sung Kwon,Oh Sung Kwon,Aishwarya Aravamudhan,Jing Ling,Andreas Dendorfer,Changmin Xie,Ohyun Kwon,Emily H. Cheng,Kevin J. Whitehead,Thomas Gudermann,Russel S. Richardson,Frank B. Sachse,Johann Schredelseker,Kenneth W. Spitzer,Dipayan Chaudhuri,Stavros G. Drakos +24 more
TL;DR: In this article, the role of voltage dependent anion channel 2 (VDAC2) in intracellular calcium dynamics and cardiac function was investigated in a mouse model of pressure-overload induced heart failure.
Journal ArticleDOI
Remodeling of t-system and proteins underlying excitation-contraction coupling in aging versus failing human heart.
Yankun Lyu,Vipin K. Verma,Younjee Lee,Iosif Taleb,Iosif Taleb,Rachit Badolia,Thirupura S. Shankar,Christos P. Kyriakopoulos,Christos P. Kyriakopoulos,Craig H. Selzman,Craig H. Selzman,William T. Caine,Rami Alharethi,Sutip Navankasattusas,Thomas Seidel,Stavros G. Drakos,Stavros G. Drakos,Frank B. Sachse +17 more
TL;DR: In this article, the transverse tubular system (t-system) and proteins underlying excitation-contraction coupling in cardiomyocytes are characteristically remodeled with age and they shed light on mechanisms of this remodeling and identified similarities and differences to chronic heart failure (HF) associated remodeling remain ill-defined.