Jordan A. Berg

TL;DR: It is shown that the lysosome-like vacuole maintains mitochondrial respiration by spatially compartmentalizing amino acids and identifies vacuolar amino acid compartmentation as a cellular strategy to minimize amino acid toxicity.

TL;DR: It is found that alteration of the pyruvate-lactate axis is a fundamental and early feature of cardiac hypertrophy and failure.

TL;DR: Genetic studies in Drosophila suggest that changes in cellular pyruvate metabolism are necessary and sufficient to promote cancer initiation, and loss of Mpc1 prior to a tumorigenic stimulus doubled the frequency of adenoma formation and produced higher grade tumors.

TL;DR: It is demonstrated that the acylated form of ACP is an acetyl-CoA-dependent allosteric activator of the LYR protein family used to stimulate ETC biogenesis and could provide an elegant mechanism for coordinating the assembly of ETC complexes with one another and with substrate availability.

TL;DR: It is shown that hypomorphic mtFAS mutant mouse skeletal myoblast cell lines display a severe loss of electron transport chain (ETC) complexes and exhibit compensatory metabolic activities including reductive carboxylation, suggesting that ETC activity in mammals is profoundly controlled bymtFAS function.