R
Rainer Schimpf
Researcher at Heidelberg University
Publications - 152
Citations - 9050
Rainer Schimpf is an academic researcher from Heidelberg University. The author has contributed to research in topics: Short QT syndrome & Brugada syndrome. The author has an hindex of 44, co-authored 150 publications receiving 8450 citations. Previous affiliations of Rainer Schimpf include Oulu University Hospital & University of Mannheim.
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Journal ArticleDOI
Loss-of-Function Mutations in the Cardiac Calcium Channel Underlie a New Clinical Entity Characterized by ST-Segment Elevation, Short QT Intervals, and Sudden Cardiac Death
Charles Antzelevitch,Guido D. Pollevick,Jonathan M. Cordeiro,Oscar Casis,Michael C. Sanguinetti,Yoshiyasu Aizawa,Alejandra Guerchicoff,Ryan Pfeiffer,Antonio Oliva,Bernd Wollnik,Philip Gelber,Elias P. Bonaros,Elena Burashnikov,Yuesheng Wu,John D. Sargent,Stefan Schickel,Ralf Oberheiden,Atul Bhatia,Li Fern Hsu,Michel Haïssaguerre,Rainer Schimpf,Martin Borggrefe,Christian Wolpert +22 more
TL;DR: This is the first report of loss-of-function mutations in genes encoding the cardiac L-type calcium channel to be associated with a familial sudden cardiac death syndrome in which a Brugada syndrome phenotype is combined with shorter-than-normal QT intervals.
Journal ArticleDOI
Sudden death associated with short-QT syndrome linked to mutations in HERG.
Ramon Brugada,Kui Hong,Robert Dumaine,Jonathan M. Cordeiro,Fiorenzo Gaita,Martin Borggrefe,Teresa M. Menendez,Josep Brugada,Guido D. Pollevick,Christian Wolpert,Elena Burashnikov,Kiyotaka Matsuo,Yue Sheng Wu,Alejandra Guerchicoff,Francesca Bianchi,Carla Giustetto,Rainer Schimpf,Pedro Brugada,Charles Antzelevitch +18 more
TL;DR: The genetic basis for a new clinical entity characterized by sudden death and short-QT intervals in the ECG is described and a novel genetic and biophysical mechanism responsible for sudden death in infants, children, and young adults caused by mutations in KCNH2 is demonstrated.
Journal ArticleDOI
Short QT Syndrome A Familial Cause of Sudden Death
Fiorenzo Gaita,Carla Giustetto,Francesca Bianchi,Christian Wolpert,Rainer Schimpf,Riccardo Riccardi,Stefano Grossi,E. Richiardi,Martin Borggrefe +8 more
TL;DR: The short QT syndrome is characterized by familial sudden death, short refractory periods, and inducible ventricular fibrillation, which is related to a high risk of sudden death in young, otherwise healthy subjects.
Journal ArticleDOI
Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death
Connie R. Bezzina,Julien Barc,Yuka Mizusawa,Carol Ann Remme,Jean-Baptiste Gourraud,Floriane Simonet,Floriane Simonet,Floriane Simonet,Arie O. Verkerk,Peter J. Schwartz,Lia Crotti,Federica Dagradi,Pascale Guicheney,Pascale Guicheney,Véronique Fressart,Véronique Fressart,Antoine Leenhardt,Antoine Leenhardt,Charles Antzelevitch,Susan Bartkowiak,Martin Borggrefe,Rainer Schimpf,Eric Schulze-Bahr,Sven Zumhagen,Elijah R. Behr,Rachel Bastiaenen,Jacob Tfelt-Hansen,Jacob Tfelt-Hansen,Morten S. Olesen,Morten S. Olesen,Stefan Kääb,Britt M. Beckmann,Peter Weeke,Hiroshi Watanabe,Naoto Endo,Tohru Minamino,Minoru Horie,Seiko Ohno,Kanae Hasegawa,Naomasa Makita,Akihiko Nogami,Wataru Shimizu,Takeshi Aiba,Philippe Froguel,Philippe Froguel,Philippe Froguel,Beverley Balkau,Beverley Balkau,Olivier Lantieri,Margherita Torchio,Cornelia Wiese,David Weber,Rianne Wolswinkel,Ruben Coronel,Bas J. Boukens,Stéphane Bézieau,Eric Charpentier,Eric Charpentier,Eric Charpentier,Stéphanie Chatel,Aurore Despres,Françoise Gros,Françoise Gros,Françoise Gros,Florence Kyndt,Simon Lecointe,Pierre Lindenbaum,Vincent Portero,Vincent Portero,Vincent Portero,Jade Violleau,Manfred Gessler,Hanno L. Tan,Dan M. Roden,Vincent M. Christoffels,Hervé Le Marec,Arthur A.M. Wilde,Vincent Probst,Jean-Jacques Schott,Christian Dina,Richard Redon +80 more
TL;DR: The association signals at SCN5A-SCN10A demonstrate that genetic polymorphisms modulating cardiac conduction can also influence susceptibility to cardiac arrhythmia and indicate that common genetic variation can have a strong impact on the predisposition to rare diseases.
Journal ArticleDOI
Long-Term Prognosis of Individuals With Right Precordial ST-Segment–Elevation Brugada Syndrome
Lars Eckardt,Vincent Probst,Jeroen P.P. Smits,Eric Schulze Bahr,Christian Wolpert,Rainer Schimpf,Thomas Wichter,Pierre Boisseau,Achim Heinecke,Günter Breithardt,Martin Borggrefe,Herve LeMarec,Dirk Böcker,Arthur A.M. Wilde +13 more
TL;DR: A very low incidence of severe arrhythmic events, particularly in asymptomatic individuals, was found during follow-up and programmed electrical stimulation showed very little accuracy in predicting outcome.