D
David Weber
Researcher at University of Würzburg
Publications - 6
Citations - 718
David Weber is an academic researcher from University of Würzburg. The author has contributed to research in topics: Promoter & Transcriptional regulation. The author has an hindex of 6, co-authored 6 publications receiving 616 citations.
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Journal ArticleDOI
Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death
Connie R. Bezzina,Julien Barc,Yuka Mizusawa,Carol Ann Remme,Jean-Baptiste Gourraud,Floriane Simonet,Floriane Simonet,Floriane Simonet,Arie O. Verkerk,Peter J. Schwartz,Lia Crotti,Federica Dagradi,Pascale Guicheney,Pascale Guicheney,Véronique Fressart,Véronique Fressart,Antoine Leenhardt,Antoine Leenhardt,Charles Antzelevitch,Susan Bartkowiak,Martin Borggrefe,Rainer Schimpf,Eric Schulze-Bahr,Sven Zumhagen,Elijah R. Behr,Rachel Bastiaenen,Jacob Tfelt-Hansen,Jacob Tfelt-Hansen,Morten S. Olesen,Morten S. Olesen,Stefan Kääb,Britt M. Beckmann,Peter Weeke,Hiroshi Watanabe,Naoto Endo,Tohru Minamino,Minoru Horie,Seiko Ohno,Kanae Hasegawa,Naomasa Makita,Akihiko Nogami,Wataru Shimizu,Takeshi Aiba,Philippe Froguel,Philippe Froguel,Philippe Froguel,Beverley Balkau,Beverley Balkau,Olivier Lantieri,Margherita Torchio,Cornelia Wiese,David Weber,Rianne Wolswinkel,Ruben Coronel,Bas J. Boukens,Stéphane Bézieau,Eric Charpentier,Eric Charpentier,Eric Charpentier,Stéphanie Chatel,Aurore Despres,Françoise Gros,Françoise Gros,Françoise Gros,Florence Kyndt,Simon Lecointe,Pierre Lindenbaum,Vincent Portero,Vincent Portero,Vincent Portero,Jade Violleau,Manfred Gessler,Hanno L. Tan,Dan M. Roden,Vincent M. Christoffels,Hervé Le Marec,Arthur A.M. Wilde,Vincent Probst,Jean-Jacques Schott,Christian Dina,Richard Redon +80 more
TL;DR: The association signals at SCN5A-SCN10A demonstrate that genetic polymorphisms modulating cardiac conduction can also influence susceptibility to cardiac arrhythmia and indicate that common genetic variation can have a strong impact on the predisposition to rare diseases.
Journal ArticleDOI
GATA-dependent regulatory switches establish atrioventricular canal specificity during heart development
Sonia Stefanovic,Phil Barnett,Karel van Duijvenboden,David Weber,Manfred Gessler,Vincent M. Christoffels +5 more
TL;DR: It is concluded that atrioventricular canal-specific enhancers are platforms integrating cardiac transcription factors, broadly active histone modification enzymes and localized co-factors to drive atriOVentricular Canal-specific gene activity.
Journal ArticleDOI
Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors.
Julia Heisig,David Weber,Eva Englberger,Anja Winkler,Susanne Kneitz,Wing-Kin Sung,Elmar Wolf,Martin Eilers,Chia-Lin Wei,Manfred Gessler +9 more
TL;DR: The data clearly establish the three HEY bHLH factors as highly redundant transcriptional repressors in vitro and in vivo, which explains the combinatorial action observed in different tissues with overlapping expression.
Book ChapterDOI
Hey bHLH transcription factors.
TL;DR: How expression of Hey proteins affects processes like cell fate decisions and differentiation, e.g., in cardiovascular, skeletal, and neural development or oncogenesis and how this relates to the observed developmental defects and phenotypes observed in various knockout mice is discussed.
Journal ArticleDOI
Mechanisms of epigenetic and cell-type specific regulation of Hey target genes in ES cells and cardiomyocytes.
TL;DR: The objective of this study was to elucidate the regulatory mechanisms by which Hey proteins affect gene expression in a cell type specific manner and to study target gene regulation in cardiomyocytes generated from murine embryonic stem cells (ESC).