J
Julien Barc
Researcher at French Institute of Health and Medical Research
Publications - 19
Citations - 1133
Julien Barc is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Brugada syndrome & Sudden cardiac death. The author has an hindex of 12, co-authored 19 publications receiving 963 citations. Previous affiliations of Julien Barc include University of Nantes & Centre national de la recherche scientifique.
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Journal ArticleDOI
Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death
Connie R. Bezzina,Julien Barc,Yuka Mizusawa,Carol Ann Remme,Jean-Baptiste Gourraud,Floriane Simonet,Floriane Simonet,Floriane Simonet,Arie O. Verkerk,Peter J. Schwartz,Lia Crotti,Federica Dagradi,Pascale Guicheney,Pascale Guicheney,Véronique Fressart,Véronique Fressart,Antoine Leenhardt,Antoine Leenhardt,Charles Antzelevitch,Susan Bartkowiak,Martin Borggrefe,Rainer Schimpf,Eric Schulze-Bahr,Sven Zumhagen,Elijah R. Behr,Rachel Bastiaenen,Jacob Tfelt-Hansen,Jacob Tfelt-Hansen,Morten S. Olesen,Morten S. Olesen,Stefan Kääb,Britt M. Beckmann,Peter Weeke,Hiroshi Watanabe,Naoto Endo,Tohru Minamino,Minoru Horie,Seiko Ohno,Kanae Hasegawa,Naomasa Makita,Akihiko Nogami,Wataru Shimizu,Takeshi Aiba,Philippe Froguel,Philippe Froguel,Philippe Froguel,Beverley Balkau,Beverley Balkau,Olivier Lantieri,Margherita Torchio,Cornelia Wiese,David Weber,Rianne Wolswinkel,Ruben Coronel,Bas J. Boukens,Stéphane Bézieau,Eric Charpentier,Eric Charpentier,Eric Charpentier,Stéphanie Chatel,Aurore Despres,Françoise Gros,Françoise Gros,Françoise Gros,Florence Kyndt,Simon Lecointe,Pierre Lindenbaum,Vincent Portero,Vincent Portero,Vincent Portero,Jade Violleau,Manfred Gessler,Hanno L. Tan,Dan M. Roden,Vincent M. Christoffels,Hervé Le Marec,Arthur A.M. Wilde,Vincent Probst,Jean-Jacques Schott,Christian Dina,Richard Redon +80 more
TL;DR: The association signals at SCN5A-SCN10A demonstrate that genetic polymorphisms modulating cardiac conduction can also influence susceptibility to cardiac arrhythmia and indicate that common genetic variation can have a strong impact on the predisposition to rare diseases.
Journal ArticleDOI
PDZ Domain–Binding Motif Regulates Cardiomyocyte Compartment-Specific NaV1.5 Channel Expression and Function
Diana Shy,Ludovic Gillet,Jakob Ogrodnik,Maxime Albesa,Arie O. Verkerk,Rianne Wolswinkel,Jean-Sébastien Rougier,Julien Barc,Maria C. Essers,Ninda Syam,Roos F. Marsman,Anneke M. van Mil,Samuel Rotman,Richard Redon,Connie R. Bezzina,Carol Ann Remme,Hugues Abriel +16 more
TL;DR: In vivo significance of the PDZ domain–binding motif in the correct expression of NaV1.5 at the lateral cardiomyocyte membrane is demonstrated and the clinical relevance of the SIV motif in cardiac disease is revealed.
Journal ArticleDOI
Role of common and rare variants in SCN10A: Results from the Brugada syndrome QRS locus gene discovery collaborative study
Elijah R. Behr,Eleonora Savio-Galimberti,Julien Barc,Anders G. Holst,Anders G. Holst,Anders G. Holst,Evmorfia Petropoulou,Bram P. Prins,Javad Jabbari,Javad Jabbari,Javad Jabbari,Margherita Torchio,Myriam Berthet,Myriam Berthet,Myriam Berthet,Yuka Mizusawa,Tao Yang,Eline A. Nannenberg,Federica Dagradi,Peter Weeke,Rachel Bastiaenan,Michael J. Ackerman,Stig Haunsø,Stig Haunsø,Antoine Leenhardt,Stefan Kääb,Vincent Probst,Richard Redon,Sanjay Sharma,Arthur A.M. Wilde,Jacob Tfelt-Hansen,Jacob Tfelt-Hansen,Peter J. Schwartz,Dan M. Roden,Connie R. Bezzina,Morten S. Olesen,Morten S. Olesen,Dawood Darbar,Pascale Guicheney,Pascale Guicheney,Pascale Guicheney,Lia Crotti,Lia Crotti,Yalda Jamshidi +43 more
TL;DR: Rare variants in the screened QRS-associated genes (including SCN10A) are not responsible for a significant proportion of SCN5A mutation negative BrS, as did rare variants in isolated patients.
Journal ArticleDOI
Screening for copy number variation in genes associated with the long QT syndrome: clinical relevance.
Julien Barc,François Briec,Sébastien Schmitt,Florence Kyndt,Martine Le Cunff,Martine Le Cunff,Martine Le Cunff,Estelle Baron,Estelle Baron,Estelle Baron,Claude Vieyres,Frederic Sacher,Richard Redon,Richard Redon,Richard Redon,Cédric Le Caignec,Hervé Le Marec,Vincent Probst,Jean-Jacques Schott +18 more
TL;DR: This study demonstrates that CNVs in KCNQ1 and KCNH2 explain around 3% of LQTS in patients with no point mutation in these genes, which is likely higher than the frequency of point mutations in ANKB, KCNE1, KC NE2, KCNJ2, CACNA1C, CAV3, SCN4B, AKAP9, and SNTA1 together.
Journal ArticleDOI
The Brugada Syndrome Susceptibility Gene HEY2 Modulates Cardiac Transmural Ion Channel Patterning and Electrical Heterogeneity
Christiaan C. Veerman,Svitlana Podliesna,Rafik Tadros,Elisabeth M. Lodder,Isabella Mengarelli,Berend de Jonge,Leander Beekman,Julien Barc,Ronald Wilders,Arthur A.M. Wilde,Bastiaan J. Boukens,Ruben Coronel,Arie O. Verkerk,Carol Ann Remme,Connie R. Bezzina +14 more
TL;DR: This study uncovers a role of HEY2 in the normal transmural electrophysiological gradient in the ventricle and provides compelling evidence that genetic variation at 6q22.31 (rs9388451) is associated with Brugada syndrome through aHEY2-dependent alteration of ion channel expression across the cardiac ventricular wall.