Yuka Mizusawa

TL;DR: The association signals at SCN5A-SCN10A demonstrate that genetic polymorphisms modulating cardiac conduction can also influence susceptibility to cardiac arrhythmia and indicate that common genetic variation can have a strong impact on the predisposition to rare diseases.

TL;DR: The PRAETORIAN trial is a randomized trial that aims to gain scientific evidence for the use of the subcutaneous ICD compared with the transvenous ICD in a population of patients with conventional ICD with respect to major ICD-related adverse events.

TL;DR: The most recent advances in LQTS clinical diagnostics as well as genetics are described and a more complex genetic model intertwined with genetic common polymorphisms that have a mild to moderate effect on disease expression are described.

TL;DR: Rare variants in the screened QRS-associated genes (including SCN10A) are not responsible for a significant proportion of SCN5A mutation negative BrS, as did rare variants in isolated patients.

TL;DR: The KCNJ2 gene screening in atypical ATS phenotypes is of clinical importance because more than half of mutation carriers express atypicals phenotypes, despite their arrhythmia severity.