S
Simon Lecointe
Researcher at University of Nantes
Publications - 18
Citations - 862
Simon Lecointe is an academic researcher from University of Nantes. The author has contributed to research in topics: Brugada syndrome & Biology. The author has an hindex of 9, co-authored 13 publications receiving 660 citations. Previous affiliations of Simon Lecointe include French Institute of Health and Medical Research.
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Journal ArticleDOI
Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death
Connie R. Bezzina,Julien Barc,Yuka Mizusawa,Carol Ann Remme,Jean-Baptiste Gourraud,Floriane Simonet,Floriane Simonet,Floriane Simonet,Arie O. Verkerk,Peter J. Schwartz,Lia Crotti,Federica Dagradi,Pascale Guicheney,Pascale Guicheney,Véronique Fressart,Véronique Fressart,Antoine Leenhardt,Antoine Leenhardt,Charles Antzelevitch,Susan Bartkowiak,Martin Borggrefe,Rainer Schimpf,Eric Schulze-Bahr,Sven Zumhagen,Elijah R. Behr,Rachel Bastiaenen,Jacob Tfelt-Hansen,Jacob Tfelt-Hansen,Morten S. Olesen,Morten S. Olesen,Stefan Kääb,Britt M. Beckmann,Peter Weeke,Hiroshi Watanabe,Naoto Endo,Tohru Minamino,Minoru Horie,Seiko Ohno,Kanae Hasegawa,Naomasa Makita,Akihiko Nogami,Wataru Shimizu,Takeshi Aiba,Philippe Froguel,Philippe Froguel,Philippe Froguel,Beverley Balkau,Beverley Balkau,Olivier Lantieri,Margherita Torchio,Cornelia Wiese,David Weber,Rianne Wolswinkel,Ruben Coronel,Bas J. Boukens,Stéphane Bézieau,Eric Charpentier,Eric Charpentier,Eric Charpentier,Stéphanie Chatel,Aurore Despres,Françoise Gros,Françoise Gros,Françoise Gros,Florence Kyndt,Simon Lecointe,Pierre Lindenbaum,Vincent Portero,Vincent Portero,Vincent Portero,Jade Violleau,Manfred Gessler,Hanno L. Tan,Dan M. Roden,Vincent M. Christoffels,Hervé Le Marec,Arthur A.M. Wilde,Vincent Probst,Jean-Jacques Schott,Christian Dina,Richard Redon +80 more
TL;DR: The association signals at SCN5A-SCN10A demonstrate that genetic polymorphisms modulating cardiac conduction can also influence susceptibility to cardiac arrhythmia and indicate that common genetic variation can have a strong impact on the predisposition to rare diseases.
Journal ArticleDOI
Genetic association analyses highlight biological pathways underlying mitral valve prolapse
Christian Dina,Nabila Bouatia-Naji,Nathan R. Tucker,Francesca N. Delling,Francesca N. Delling,Katelynn Toomer,Ronen Durst,Maelle Perrocheau,Leticia Fernández-Friera,Leticia Fernández-Friera,Jorge Solis,Jorge Solis,Thierry Le Tourneau,Ming-Huei Chen,Ming-Huei Chen,Vincent Probst,Yohan Bossé,Philippe Pibarot,Diana Zelenika,Mark Lathrop,Serge Hercberg,Ronan Roussel,Emelia J. Benjamin,Emelia J. Benjamin,Fabrice Bonnet,Su Hao Lo,Elena Dolmatova,Floriane Simonet,Simon Lecointe,Florence Kyndt,Richard Redon,Hervé Le Marec,Philippe Froguel,Patrick T. Ellinor,Patrick T. Ellinor,Ramachandran S. Vasan,Patrick Bruneval,Roger R. Markwald,Russell A. Norris,David J. Milan,Susan A. Slaugenhaupt,Robert A. Levine,Jean-Jacques Schott,Albert Hagège,Xavier Jeunemaitre +44 more
TL;DR: The first risk loci for MVP are identified and new mechanisms involved in mitral valve regurgitation are suggested, including tensin 1, a focal adhesion protein involved in cytoskeleton organization, which is shown during valve morphogenesis.
Journal ArticleDOI
Filamin-A-Related Myxomatous Mitral Valve Dystrophy: Genetic, Echocardiographic and Functional Aspects
Aurélie Lardeux,Florence Kyndt,Simon Lecointe,Hervé Le Marec,Jean Mérot,Jean-Jacques Schott,Thierry Le Tourneau,Vincent Probst +7 more
TL;DR: The genetic, echocardiographic and functional aspects of the filamin-A-related myxomatous mitral valve dystrophy are described.
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New insights into mitral valve dystrophy: a Filamin-A genotype-phenotype and outcome study.
Thierry Le Tourneau,Solena Le Scouarnec,Caroline Cueff,Daniel Bernstein,Jan J.J. Aalberts,Simon Lecointe,Jean Mérot,Jonathan A. Bernstein,Toon Oomen,Christian Dina,Matilde Karakachoff,Hubert Desal,Ousama Al Habash,Francesca N. Delling,Romain Capoulade,Romain Capoulade,Albert J. H. Suurmeijer,David J. Milan,Russell A. Norris,Roger R. Markwald,Elena Aikawa,Susan A. Slaugenhaupt,Xavier Jeunemaitre,Xavier Jeunemaitre,Albert Hagège,Albert Hagège,Jean Christian Roussel,Jean Noël Trochu,Robert A. Levine,F. Kyndt,Vincent Probst,Hervé Le Marec,Jean-Jacques Schott +32 more
TL;DR: FLNA-MVD has unique features with both MVP and paradoxical restricted motion in diastole, sub-valvular mitral apparatus impairment and polyvalvULAR lesions in males, and conveys a substantial lifetime risk of valve surgery in men.
Journal ArticleDOI
Genetic Association Analyses Highlight IL6, ALPL, and NAV1 As 3 New Susceptibility Genes Underlying Calcific Aortic Valve Stenosis.
Sébastien Thériault,Christian Dina,David Messika-Zeitoun,Solena Le Scouarnec,Romain Capoulade,Nathalie Gaudreault,Sidwell Rigade,Zhonglin Li,Floriane Simonet,Maxime Lamontagne,Marie-Annick Clavel,Benoit J. Arsenault,Anne-Sophie Boureau,Simon Lecointe,Estelle Baron,Stéphanie Bonnaud,Matilde Karakachoff,Eric Charpentier,Imen Fellah,Jean-Christian Roussel,Jean Philippe Verhoye,Christophe Baufreton,Vincent Probst,Ronan Roussel,Richard Redon,François Dagenais,Philippe Pibarot,Patrick Mathieu,Thierry Le Tourneau,Yohan Bossé,Jean-Jacques Schott +30 more
TL;DR: This study implicates 3 new genetic loci in CAVS pathogenesis, which constitute novel targets for the development of therapeutic agents, and indicates genetic correlation between CAVS, coronary artery disease, and cardiovascular risk factors.